Lubner Carolyn E, Peters John W
Biosciences Center, National Renewable Energy Laboratory, 15013 Denver W Parkway, Golden, CO, 80401, USA.
Institute of Biological Chemistry, Washington State University, Pullman, WA, 99164, USA.
Chembiochem. 2017 Dec 5;18(23):2295-2297. doi: 10.1002/cbic.201700533. Epub 2017 Nov 2.
Elaborate arrays of iron-sulfur clusters link active sites via a flavin that bifurcates electrons through two energetically independent paths. The structure of the heterodisulfide reductase provides insight into how methanogens conserve energy through coupling hydrogen oxidation to coordinated exergonic heterodisulfide and endergonic ferredoxin reduction in an overall thermodynamically favorable reaction.
复杂的铁硫簇阵列通过一种黄素将活性位点连接起来，该黄素通过两条能量上独立的途径使电子发生分叉。异二硫化物还原酶的结构为产甲烷菌如何通过将氢氧化与协同的放能异二硫化物和吸能铁氧化还原蛋白还原偶联起来，在整体热力学有利的反应中保存能量提供了见解。
