Klioueva Natasja, Bovenberg Jasper, Huitinga Inge
Netherlands Brain Bank, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Legal Pathways, Haarlem, the Netherlands.
Handb Clin Neurol. 2017;145:9-12. doi: 10.1016/B978-0-12-802395-2.00002-X.
Well-characterized human brain tissue is crucial for scientific breakthroughs in research of the human brain and brain diseases. However, the collection, characterization, management, and accessibility of brain human tissue are rather complex. Well-characterized human brain tissue is often provided from private, sometimes small, brain tissue collections by (neuro)pathologic experts. However, to meet the increasing demand for human brain tissue from the scientific community, many professional brain-banking activities aiming at both neurologic and psychiatric diseases as well as healthy controls are currently being initiated worldwide. Professional biobanks are open-access and in many cases run donor programs. They are therefore costly and need effective business plans to guarantee long-term sustainability. Here we discuss the ethical, legal, managerial, and financial aspects of professional brain banks.
特征明确的人脑组织对于人脑及脑部疾病研究的科学突破至关重要。然而，人脑组织的采集、特征描述、管理及获取相当复杂。特征明确的人脑组织通常由（神经）病理专家从私人的、有时规模较小的脑组织库提供。然而，为满足科学界对人脑组织日益增长的需求，目前全球正在启动许多针对神经和精神疾病以及健康对照的专业脑库活动。专业生物样本库是开放获取的，在许多情况下还开展捐赠者项目。因此，它们成本高昂，需要有效的商业计划来保证长期可持续性。在此，我们讨论专业脑库的伦理、法律、管理和财务方面的问题。
