Larsen C J
Unité 301 INSERM, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1988;30(1-2):39-43.
Proto-oncogenes, which have been widely implicated in the pathogenesis of malignant human tumors, frequently demonstrate restriction fragment length polymorphism (RFLP). Population studies of such restriction alleles is of potential interest for genetic analysis of cancer susceptibility. Some of the initial date of Krontiris et al (1985) showing a significant increase of rare c-ha-ras-l alleles in individuals with tumors, have been confirmed in certain types of cancer (breast cancer, lung adenocarcinoma), whereas others have been refuted (myelodysplasia, melanoma, colon adenocarcinoma). Other significant associations have been found between other proto-oncogene RLFPs and tumors (c-mos and breast cancer, c-raf and non Hodgkins lymphoma, L-myc and lung carcinoma metastasis). Although they are controversial, these studies should be extended, in order to determine whether the presence of certain alleles is a contributing factor in the development of certain tumors.
原癌基因在人类恶性肿瘤的发病机制中具有广泛影响，常表现出限制性片段长度多态性（RFLP）。对这类限制性等位基因的群体研究对于癌症易感性的遗传分析具有潜在意义。Krontiris等人（1985年）的一些初步数据表明，肿瘤患者中罕见的c-ha-ras-1等位基因显著增加，这在某些类型的癌症（乳腺癌、肺腺癌）中得到了证实，而在其他一些癌症（骨髓发育异常、黑色素瘤、结肠腺癌）中则被否定。在其他原癌基因RFLP与肿瘤之间还发现了其他显著关联（c-mos与乳腺癌、c-raf与非霍奇金淋巴瘤、L-myc与肺癌转移）。尽管这些研究存在争议，但仍应继续进行，以确定某些等位基因的存在是否是某些肿瘤发生的一个促成因素。
