通过 E3 连接酶 COP1 稳定转录因子。
Stabilizing the Transcription Factors by E3 Ligase COP1.
机构信息
State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, Beijing 100871, China.
College of Life Sciences, Capital Normal University, Beijing 100048, China.
出版信息
Trends Plant Sci. 2017 Dec;22(12):999-1001. doi: 10.1016/j.tplants.2017.09.012. Epub 2017 Oct 4.
Photomorphogenesis is oppositely regulated by two groups of transcription factors. CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) degrades the positive factors but stabilizes the negative ones to predominantly repress photomorphogenesis. It is known that COP1 degrades substrates as an E3 ligase. Two recent studies unraveled the long-sought mechanisms of how COP1 stabilizes the negative transcription factors.
光形态建成受两组转录因子的反向调控。组成型光形态建成 1（COP1）降解正因子，但稳定负因子，主要抑制光形态建成。众所周知，COP1 作为 E3 连接酶降解底物。最近的两项研究揭示了 COP1 稳定负转录因子的长期寻求机制。
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