State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Peking University-Southern University of Science and Technology Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.
Plant Commun. 2020 Apr 12;1(3):100044. doi: 10.1016/j.xplc.2020.100044. eCollection 2020 May 11.
Green plants on the earth have evolved intricate mechanisms to acclimatize to and utilize sunlight. In , light signals are perceived by photoreceptors and transmitted through divergent but overlapping signaling networks to modulate plant photomorphogenic development. COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) was first cloned as a central repressor of photomorphogenesis in higher plants and has been extensively studied for over 30 years. It acts as a RING E3 ubiquitin ligase downstream of multiple photoreceptors to target key light-signaling regulators for degradation, primarily as part of large protein complexes. The mammalian counterpart of COP1 is a pluripotent regulator of tumorigenesis and metabolism. A great deal of information on COP1 has been derived from whole-genome sequencing and functional studies in lower green plants, which enables us to illustrate its evolutionary history. Here, we review the current understanding about COP1, with a focus on the conservation and functional diversification of COP1 and its signaling partners in different taxonomic clades.
地球上的绿色植物已经进化出复杂的机制来适应和利用阳光。在植物中，光信号被光受体感知，并通过发散但重叠的信号网络传递，以调节植物的光形态建成发育。COP1（CONSTITUTIVE PHOTOMORPHOGENIC 1）最初被克隆为高等植物光形态建成的中央抑制剂，并且已经被广泛研究了 30 多年。它作为多种光受体的下游 RING E3 泛素连接酶，作用于关键的光信号调节剂进行降解，主要作为大型蛋白质复合物的一部分。COP1 的哺乳动物对应物是肿瘤发生和代谢的多能调节剂。大量关于 COP1 的信息来自于低等绿色植物的全基因组测序和功能研究，这使我们能够说明它的进化历史。在这里，我们综述了目前对 COP1 的认识，重点介绍了 COP1 及其信号伙伴在不同分类群中的保守性和功能多样化。
