Robati Reza M, Asadi Elmira, Shafiee Anoosh, Namazi Nastaran, Talebi Atefeh
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Lasers Med Sci. 2018 Apr;33(3):461-467. doi: 10.1007/s10103-017-2351-2. Epub 2017 Oct 8.
There are different modalities for hand rejuvenation. Fractional Er:YAG laser and long pulse Nd:YAG laser were introduced for treating hand wrinkles. We plan to compare fractional Er:YAG laser and long pulse Nd:YAG laser in a randomized controlled double-blind design with multiple sessions and larger sample size in comparison with previous studies. Thirty-three participants with hand wrinkles entered this study. They were randomly allocated to undergo three monthly laser treatments on each hand, one with a fractional Er:YAG laser and the other with a long pulse Nd:YAG laser. The evaluations included assessment of clinical improvement determined by two independent dermatologists not enrolled in the treatment along with measuring skin biomechanical property of hands using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT). Moreover, potential side effects and patients' satisfaction have been documented at baseline, 1 month after each treatment, and 3 months after the final treatment session. Clinical evaluation revealed both modalities significantly reduce hand wrinkles (p value < 0.05), with no significant difference between two lasers. Mean CRRT values also decreased significantly after the laser treatment compared to those of the baseline in both laser groups. There was no serious persistent side effect after both laser treatments. Both fractional Er:YAG and long pulse Nd:YAG lasers show substantial clinical improvement of hand skin wrinkles with no serious side effects. However, combination treatment by these lasers along with the other modalities such as fat transfer could lead to better outcomes in hand rejuvenation.
IRCT2016032020468N4.
手部年轻化有不同的治疗方式。剥脱性铒钇铝石榴石激光（Fractional Er:YAG laser）和长脉冲钕钇铝石榴石激光（long pulse Nd:YAG laser）被用于治疗手部皱纹。我们计划采用随机对照双盲设计，进行多个疗程且样本量比以往研究更大的实验，比较剥脱性铒钇铝石榴石激光和长脉冲钕钇铝石榴石激光。33名有手部皱纹的参与者进入了本研究。他们被随机分配，每只手每月接受三次激光治疗，一次使用剥脱性铒钇铝石榴石激光，另一次使用长脉冲钕钇铝石榴石激光。评估包括由两名未参与治疗的独立皮肤科医生确定的临床改善情况评估，以及使用敏感的生物计量设备测量手部皮肤生物力学特性并评估皮肤共振运行时间（CRRT）。此外，在基线、每次治疗后1个月以及最后一次治疗后3个月记录了潜在的副作用和患者满意度。临床评估显示，两种治疗方式均能显著减少手部皱纹（p值<0.05），两种激光之间无显著差异。与基线相比，两个激光组在激光治疗后平均CRRT值也显著降低。两种激光治疗后均未出现严重的持续性副作用。剥脱性铒钇铝石榴石激光和长脉冲钕钇铝石榴石激光均显示手部皮肤皱纹有显著的临床改善，且无严重副作用。然而，这些激光与脂肪移植等其他方式联合治疗可能会在手部年轻化方面带来更好的效果。
IRCT2016032020468N4。
