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神经炎症 - 帕金森病纹状体多巴胺能退行性变的主要原因。

Neuroinflammation - A major cause for striatal dopaminergic degeneration in Parkinson's disease.

机构信息

Neuropharmacology Division, I. S. F. College of Pharmacy, Moga 142001, Punjab, India.

Neuropharmacology Division, I. S. F. College of Pharmacy, Moga 142001, Punjab, India.

出版信息

J Neurol Sci. 2017 Oct 15;381:308-314. doi: 10.1016/j.jns.2017.08.3251. Epub 2017 Aug 26.

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNPc). Growing evidence suggests that neuroinflammation plays a critical role in the pathogenesis of PD. Activation of proinflammatory pathways have a deleterious effect on dopaminergic neurons and are key factors contributing to the development of disease pathology. Clinical and preclinical evidence show microglial activation, infiltration of lymphocyte, elevated levels of pro inflammatory cytokines in various regions of the brain. In this review, we have discussed the possible mechanisms which are responsible for neuroinflammatoin and the therapeutic strategies to rescue dopaminergic neurons from these deleterious events.

摘要

帕金森病(PD)是一种进行性神经退行性疾病,其特征是黑质致密部(SNPc)中的多巴胺能神经元退化。越来越多的证据表明,神经炎症在 PD 的发病机制中起着关键作用。促炎途径的激活对多巴胺能神经元有有害影响,是导致疾病病理发展的关键因素。临床和临床前证据表明,小胶质细胞激活、淋巴细胞浸润、大脑各个区域促炎细胞因子水平升高。在这篇综述中,我们讨论了导致神经炎症的可能机制,以及从这些有害事件中拯救多巴胺能神经元的治疗策略。

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