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2
Hyperuricemia, Type 2 Diabetes Mellitus, and Hypertension: an Emerging Association.高尿酸血症、2 型糖尿病和高血压：一种新出现的关联。
Curr Hypertens Rep. 2017 Sep;19(9):69. doi: 10.1007/s11906-017-0770-x.
3
Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies.血清尿酸水平与多种健康结局：观察性研究、随机对照试验及孟德尔随机化研究证据的综合评价
BMJ. 2017 Jun 7;357:j2376. doi: 10.1136/bmj.j2376.
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Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review.果糖摄入、血清尿酸与心脏代谢紊乱：一项批判性综述。
Nutrients. 2017 Apr 18;9(4):395. doi: 10.3390/nu9040395.
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Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells.二甲双胍可改善高尿酸诱导的骨骼肌细胞胰岛素抵抗。
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6
Is Uric Acid a Missing Link between Previous Gestational Diabetes Mellitus and the Development of Type 2 Diabetes at a Later Time of Life?尿酸是既往妊娠期糖尿病与日后发生2型糖尿病之间缺失的环节吗？
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有妊娠期糖尿病病史的中国女性的尿酸与糖尿病风险

Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus.

作者信息

Leng Junhong, Wang Leishen, Wang Jing, Li Weiqin, Liu Huikun, Zhang Shuang, Li Lili, Tian Huiguang, Xun Pengcheng, Yang Xilin, Yu Zhijie, Hu Gang

机构信息

Tianjin Women's and Children's Health Center, Tianjin, China.

Tianjin Women's and Children's Health Center, Tianjin, China; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.

出版信息

Diabetes Res Clin Pract. 2017 Dec;134:72-79. doi: 10.1016/j.diabres.2017.09.015. Epub 2017 Oct 6.

DOI:10.1016/j.diabres.2017.09.015
PMID:28993154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5723553/
Abstract

AIMS

To assess the association of uric acid (UA) with the risks of postpartum type 2 diabetes and prediabetes among women with prior gestational diabetes mellitus (GDM).

METHODS

We performed a cross-sectional study of 1262 GDM women at 1-5 years after delivery using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Program. Logistic regression models were used to estimate the association of different levels of serum UA with the risks of type 2 diabetes and prediabetes.

RESULTS

The multivariable-adjusted odds ratios (ORs) across quartiles of serum UA were 1.00, 1.23 (95% confidence interval [CI] 0.55-2.78), 2.05 (95% CI 0.96-4.39), and 3.17 (95% CI 1.54-6.55) (P < 0.001) for type 2 diabetes, and 1.00, 1.50 (95% CI 1.03-2.19), 2.28 (95% CI 1.58-3.30), and 2.88 (95% CI 1.99-4.17) (P < 0.001) for prediabetes, respectively. Restricted cubic splines models showed positive linear associations of serum UA as a continuous variable with the risks of type 2 diabetes and prediabetes. This positive association was significant when stratified by healthy weight and overweight participants.

CONCLUSIONS

Serum UA levels have a graded positive association with the risks of type 2 diabetes and prediabetes among Chinese with a history of GDM.

摘要

目的

评估尿酸（UA）与既往患有妊娠期糖尿病（GDM）的女性产后2型糖尿病和糖尿病前期风险之间的关联。

方法

我们利用天津妊娠期糖尿病预防项目的基线数据，对1262名产后1至5年的GDM女性进行了横断面研究。采用逻辑回归模型来估计不同血清尿酸水平与2型糖尿病和糖尿病前期风险之间的关联。

结果

血清尿酸四分位数的多变量调整比值比（OR）在2型糖尿病中分别为1.00、1.23（95%置信区间[CI] 0.55 - 2.78）、2.05（95% CI 0.96 - 4.39）和3.17（95% CI 1.54 - 6.55）（P < 0.001），在糖尿病前期中分别为1.00、1.50（95% CI 1.03 - 2.19）、2.28（95% CI 1.58 - 3.30）和2.88（95% CI 1.99 - 4.17）（P < 0.001）。受限立方样条模型显示，血清尿酸作为连续变量与2型糖尿病和糖尿病前期风险呈正线性关联。当按健康体重和超重参与者分层时，这种正关联具有显著性。

结论

在中国有GDM病史的人群中，血清尿酸水平与2型糖尿病和糖尿病前期风险呈分级正相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d2/5723553/c8e7d823c4d0/nihms914789f3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d2/5723553/99973c34635b/nihms914789f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d2/5723553/99973c34635b/nihms914789f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d2/5723553/8a852c353774/nihms914789f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d2/5723553/c8e7d823c4d0/nihms914789f3a.jpg