Iraj Bijan, Feizi Awat, Abdar-Esfahani Morteza, Heidari-Beni Motahar, Zare Maryam, Amini Masoud, Parsa Fatemeh
Assistant Professor, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Associate Professor of Biostatistics, Department of Biostatistics and Epidemiology, School of Health, and Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2014 Mar;19(3):262-7.
Excess serum uric acid (UA) accumulation can lead to various diseases. Increasing evidences reveal that UA may have a key role in the pathogenesis of metabolic syndrome. Little is known about the associations of UA levels with cardiometabolic risk factors in prediabetic individuals. This study was designed to evaluate the association between UA and cardiometabolic risk factors in prediabetic subjects with family history of diabetes compared with those with normal glucose tolerance (NGT).
In a cross-sectional setting, a sample containing 643 (302 prediabetic subjects and 341 normal) of the first-degree relatives of diabetic patients aged 35-55-years old were investigated. Samples were assessed in prediabetic and normal groups using glucose tolerance categories. Prediabetes was defined based on American Diabetes Association (ADA) criteria. Body weight and height, systolic and diastolic blood pressure (SBP and DBP), UA, creatinine (Cr), albumin (Alb), fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and lipid profiles were measured and compared between two groups.
Prediabetic persons were older and obese than normal persons. Also, prediabetic persons (5.2 ± 1.3 mg/dl) had significantly higher UA than normal persons (4.9 ± 1.4 mg/dl) (P < 0.05). FBG after 0, 30, 60, and 120 min in prediabetic were higher than normal persons (P < 0.001). With respect to metabolic parameters, the patients in the higher UA quartiles exhibited higher levels of body mass index (BMI), SBP, FBG and triglycerides (TG). The higher quartiles of UA tended to be associated with higher BMI and higher total cholesterol (TC) in females prediabetic persons. Based on logistic regression analysis in different models, UA was positively (odds ratio (OR) >1, P < 0.05) associated with glucose tolerance categories. This association remained statistically significant after adjusting the effects of age and BMI. Also, the association between glucose tolerance categories and UA were positively significant in both genders.
High UA level was associated with some cardiometabolic risk factors in prediabetic individuals compared with normal person. UA level was also a significant predictor for prediabetes condition.
血清尿酸（UA）过量积累可导致多种疾病。越来越多的证据表明，UA可能在代谢综合征的发病机制中起关键作用。关于糖尿病前期个体中UA水平与心血管代谢危险因素之间的关联知之甚少。本研究旨在评估有糖尿病家族史的糖尿病前期受试者与糖耐量正常（NGT）者相比，UA与心血管代谢危险因素之间的关联。
在一项横断面研究中，对643名年龄在35 - 55岁的糖尿病患者一级亲属样本（302名糖尿病前期受试者和341名正常者）进行了调查。根据糖耐量类别对糖尿病前期和正常组的样本进行评估。糖尿病前期根据美国糖尿病协会（ADA）标准定义。测量并比较两组的体重、身高、收缩压和舒张压（SBP和DBP）、UA、肌酐（Cr）、白蛋白（Alb）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）和血脂谱。
糖尿病前期患者比正常人年龄更大且更肥胖。此外，糖尿病前期患者（5.2±1.3mg/dl）的UA水平显著高于正常人（4.9±1.4mg/dl）（P<0.05）。糖尿病前期患者0、30、60和120分钟后的FBG高于正常人（P<0.001）。关于代谢参数，UA四分位数较高的患者表现出较高的体重指数（BMI）、SBP（收缩压）、FBG（空腹血糖）和甘油三酯（TG）。在糖尿病前期女性中，UA较高的四分位数往往与较高的BMI和较高的总胆固醇（TC）相关。基于不同模型的逻辑回归分析，UA与糖耐量类别呈正相关（优势比（OR）>1，P<0.05）。在调整年龄和BMI的影响后，这种关联仍具有统计学意义。此外，糖耐量类别与UA之间的关联在两性中均呈正显著相关。
与正常人相比，糖尿病前期个体中高UA水平与一些心血管代谢危险因素相关。UA水平也是糖尿病前期状态的一个重要预测指标。
