Xu Yang-Yang, Cai Hao, Duan Yu, Pei Ke, Fan Kai-Lei, Liu Xiao, Cao Gang
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhongguo Zhong Yao Za Zhi. 2017 Mar;42(5):856-862. doi: 10.19540/j.cnki.cjcmm.20170121.005.
Ulcerative colitis is a chronic, nonspecific and complex intestinal disease. The current clinical treatment guideline of this disease recommends a variety of options with oral western medicines, such as aminosalicylic acids, glucocorticosteroids, and immunosuppressors. However, due to their unstable therapeutic effects, high toxicities, and strong drug dependence, they are not suitable for long-term administration. Baizhu Shaoyao powder, a traditional Chinese medicinal prescription, is clinically and commonly used for tonifying spleen and softening liver as well as eliminating dampness and relieving diarrhea. Recent researches suggest that Baizhu Shaoyao powder has significant effect in the treatment of ulcerative colitis. This article reviewed the research progress on the curative effect and action mechanism of Baizhu Shaoyao powder in treating ulcerative colitis, and provided the ideas and directions for its further research in future.
溃疡性结肠炎是一种慢性、非特异性的复杂肠道疾病。该疾病目前的临床治疗指南推荐了多种口服西药治疗方案，如氨基水杨酸类、糖皮质激素和免疫抑制剂。然而，由于它们的治疗效果不稳定、毒性高且药物依赖性强，不适合长期服用。白术芍药散是一种中药方剂，临床常用于健脾柔肝、祛湿止泻。近期研究表明，白术芍药散在治疗溃疡性结肠炎方面具有显著疗效。本文综述了白术芍药散治疗溃疡性结肠炎的疗效及作用机制的研究进展，并为其未来的进一步研究提供了思路和方向。
