Imes S, Pinchbeck B, Thomson A B
Nutrition and Metabolism Research Group, Faculty of Medicine, University of Alberta, Edmonton, Canada.
Digestion. 1988;39(1):7-19. doi: 10.1159/000199602.
A prospective study was undertaken to establish the role of individualized diet counselling in the management of 137 outpatients with Crohn's disease. Individualized dietary counselling for 6 months was associated with a significant decrease in the Crohn's disease activity index, an increased incidence of disease remission, a decreased need for prednisone and Salazopyrin therapy, a reduction in the number of days spent in hospital, and a reduction in the amount of time lost from work due to Crohn's disease, when compared with control patients who did not receive dietary counselling but who were seen regularly in follow-up under similar circumstances. Improvement with diet counselling was more likely to occur in patients who had not previously been subjected to small bowel resection, and occurred in patients with active or inactive disease. The effect of counselling 58 patients was assessed over a further 6 months (for a total 12-month period); there was a persistently reduced Crohn's disease activity index and a continued decreased number of lost days of work. The mechanism for these beneficial effects of diet counselling was not established. It is suggested that individualized diet counselling, aimed at optimizing the patient's nutritional status, may play a role in the management of patients with Crohn's disease.
开展了一项前瞻性研究，以确定个体化饮食咨询在137例克罗恩病门诊患者管理中的作用。与未接受饮食咨询但在类似情况下定期接受随访的对照患者相比，为期6个月的个体化饮食咨询与克罗恩病活动指数显著降低、疾病缓解发生率增加、泼尼松和柳氮磺胺吡啶治疗需求减少、住院天数减少以及因克罗恩病导致的误工时间减少有关。饮食咨询改善更可能发生在先前未接受小肠切除术的患者中，并且在活动期或非活动期疾病患者中均有发生。对58例患者的咨询效果在接下来的6个月（共12个月期间）进行了评估；克罗恩病活动指数持续降低，误工天数持续减少。饮食咨询这些有益效果的机制尚未明确。建议旨在优化患者营养状况的个体化饮食咨询可能在克罗恩病患者的管理中发挥作用。
