Imes S, Pinchbeck B, Dinwoodie A, Walker K, Thomson A B
Digestion. 1986;35(3):158-69. doi: 10.1159/000199362.
A prospective controlled 6-month study was undertaken to compare the effect of Ensure, a defined formula dietary supplement, and diet counselling in 122 outpatients with Crohn's disease. The compliance to Ensure was poor due to a high incidence of side effects. Taking any amount of Ensure reduced the need for surgery and the amount of hospitalization. There was a trend for patients receiving Ensure to experience a decline in the value of their Crohn's disease activity index (p less than 0.10). No consistent effects of Ensure were seen on the amount of work missed due to Crohn's disease, in laboratory measurements, in the need for prednisone or Salazopyrin. The vitamin B12 intake was improved, but otherwise nutrient intake declined due to a decreased food intake. Thus, certain beneficial clinical trends were associated with taking Ensure, but larger numbers of compliant patients will need to be studied to better assess the long-term role of defined formula diets in the management of outpatients with Crohn's disease.
进行了一项为期6个月的前瞻性对照研究，以比较特定配方膳食补充剂安素（Ensure）和饮食咨询对122例克罗恩病门诊患者的影响。由于副作用发生率高，患者对安素的依从性较差。服用任何剂量的安素都减少了手术需求和住院次数。接受安素治疗的患者的克罗恩病活动指数有下降趋势（p<0.10）。在因克罗恩病而缺勤的天数、实验室检测指标、使用泼尼松或柳氮磺胺吡啶的需求方面，未观察到安素的一致效果。维生素B12摄入量有所改善，但由于食物摄入量减少，其他营养素摄入量下降。因此，服用安素存在某些有益的临床趋势，但需要研究更多依从性好的患者，以更好地评估特定配方饮食在克罗恩病门诊患者管理中的长期作用。
