Stage J G, Stadil F
Scand J Gastroenterol Suppl. 1979;53:79-91.
Recent clinical experiences with 34 Z-E patients indicates that the clinical features and course of the syndrome is less dramatic than described originally. Eighty-five per cent of the patients presented stories of abdominal complaints lasting more than five years and resembling the complaints presented by duodenal ulcer patients (DU). Ulcers were present in 91 per cent of the patients. Fifty-one per cent had either ectopic or multiple ulcers. One third had a single duodenal ulcer resembling an ordinary ulcer. No patients died from complications to the ulcer diathesis. Marked hypersecretion of acid and gastrin was present in the ZE group (BAO:33.7 +/- 7.4; PAO:62.8 +/- 6.1 meq H+/h; gastrin: 5094 pmol/l), but because of great individual variation in the ZE, some overlapping with the acid and gastrin measurements of the DU was seen. The diagnostic value of provocative tests using secretin, calcium, glucagon and food stimulations demonstrated a considerable overlapping between the two groups, indicating that these tests are of little clinical value. Tumours were found in half the patients, revealing malignancy in ten. The ZE can be diagnosed in most cases by combining symptomatology, with measurements of acid and gastrin.
最近对34例卓艾综合征（Z-E综合征）患者的临床经验表明，该综合征的临床特征和病程不如最初描述的那么显著。85%的患者有持续超过五年的腹部不适症状，与十二指肠溃疡（DU）患者的症状相似。91%的患者存在溃疡。51%的患者有异位溃疡或多发溃疡。三分之一的患者有单个类似普通溃疡的十二指肠溃疡。没有患者死于溃疡素质的并发症。卓艾综合征组存在明显的胃酸和胃泌素高分泌（基础胃酸排量：33.7±7.4；最大胃酸排量：62.8±6.1 meq H⁺/h；胃泌素：5094 pmol/l），但由于卓艾综合征患者个体差异很大，所以在胃酸和胃泌素测量值上与十二指肠溃疡患者有一些重叠。使用促胰液素、钙、胰高血糖素和食物刺激进行激发试验的诊断价值表明两组之间有相当大的重叠，这表明这些试验临床价值不大。半数患者发现肿瘤，其中10例为恶性肿瘤。大多数情况下，结合症状学以及胃酸和胃泌素的测量可诊断卓艾综合征。
