• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

生物性酮醛甲基乙二醛在中国仓鼠卵巢细胞中诱导姐妹染色单体交换

Induction of sister-chromatid exchanges in Chinese hamster ovary cells by the biotic ketoaldehyde methylglyoxal.

作者信息

Faggin P, Bassi A M, Finollo R, Brambilla G

出版信息

Mutat Res. 1985 Nov;144(3):189-91. doi: 10.1016/0165-7992(85)90138-1.

DOI:10.1016/0165-7992(85)90138-1
PMID:4058437
Abstract

The number of sister-chromatid exchanges (SCEs) per metaphase was determined in Chinese hamster ovary cells after 16 h exposure to methylglyoxal (MG) concentrations ranging from 0.1 to 0.75 mM. MG produced an increase of SCE frequency that proved to be dose-dependent, and to reach a maximum of 2 X baseline at the highest nontoxic concentration (0.5 mM).

摘要

将中国仓鼠卵巢细胞暴露于浓度范围为0.1至0.75 mM的甲基乙二醛(MG)中16小时后,测定每个中期的姐妹染色单体交换(SCE)数量。MG使SCE频率增加,这被证明是剂量依赖性的,并且在最高无毒浓度(0.5 mM)下达到基线的2倍最大值。

相似文献

1
Induction of sister-chromatid exchanges in Chinese hamster ovary cells by the biotic ketoaldehyde methylglyoxal.生物性酮醛甲基乙二醛在中国仓鼠卵巢细胞中诱导姐妹染色单体交换
Mutat Res. 1985 Nov;144(3):189-91. doi: 10.1016/0165-7992(85)90138-1.
2
Induction of sister chromatid exchanges by ergot compounds in Chinese hamster ovary cells in vitro.麦角化合物对体外培养的中国仓鼠卵巢细胞姐妹染色单体交换的诱导作用。
Teratog Carcinog Mutagen. 1988;8(3):169-74. doi: 10.1002/tcm.1770080306.
3
Studies on the induction of sister-chromatid exchanges in Chinese hamster ovary cells by various tobacco alkaloids.
Mutat Res. 1983 Dec;124(3-4):281-6. doi: 10.1016/0165-1218(83)90199-4.
4
Analysis of bromodeoxyuridine-induced single and twin sister chromatid exchanges in tetraploid Chinese hamster ovary cells.溴脱氧尿苷诱导四倍体中国仓鼠卵巢细胞单和双姐妹染色单体交换的分析
Chromosoma. 1986;93(5):409-12. doi: 10.1007/BF00285822.
5
Induction of sister-chromatid exchanges in Chinese hamster ovary cells by thiol and hydrazine compoudns.硫醇和肼化合物对中国仓鼠卵巢细胞姐妹染色单体交换的诱导作用。
Mutat Res. 1979 Dec;68(4):351-65. doi: 10.1016/0165-1218(79)90167-8.
6
Influence of dietary carrot on cytostatic drug activity of cyclophosphamide and its main directly acting metabolite: induction of sister-chromatid exchanges in normal human lymphocytes, Chinese hamster ovary cells, and their DNA repair-deficient cell lines.膳食胡萝卜对环磷酰胺及其主要直接作用代谢物的细胞抑制药物活性的影响:在正常人淋巴细胞、中国仓鼠卵巢细胞及其DNA修复缺陷细胞系中诱导姐妹染色单体交换。
Mutat Res. 1988 Apr;198(2):327-35. doi: 10.1016/0027-5107(88)90010-3.
7
Induction of sister-chromatid exchanges (SCEs) by thymidine and the potentiation of mutagen-induced SCEs in Chinese hamster ovary cells.胸苷对中国仓鼠卵巢细胞姐妹染色单体交换(SCEs)的诱导作用以及诱变剂诱导的SCEs的增强作用。
Mutat Res. 1983 May;109(2):219-29. doi: 10.1016/0027-5107(83)90048-9.
8
Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol.邻苯基苯酚对CHO-K1细胞染色体畸变和姐妹染色单体交换的诱导作用。
Mutat Res. 1984 Oct;141(2):95-9. doi: 10.1016/0165-7992(84)90017-4.
9
Mutagenic responses of thirteen anticancer drugs on mutation induction at multiple genetic loci and on sister chromatid exchanges in Chinese hamster ovary cells.13种抗癌药物对中国仓鼠卵巢细胞多个基因位点突变诱导及姐妹染色单体交换的诱变反应。
Cancer Res. 1983 Feb;43(2):577-84.
10
Induction of sister-chromatid exchanges (SCEs) and chromosomal aberrations by mitomycin C and methyl methanesulfonate in Chinese hamster ovary cells. An evaluation of methodology for detection of SCEs and of persistent DNA lesions towards the frequencies of observed SCEs.丝裂霉素C和甲基磺酸甲酯在中国仓鼠卵巢细胞中诱导姐妹染色单体交换(SCEs)和染色体畸变。对用于检测SCEs的方法以及针对所观察到的SCEs频率的持续性DNA损伤的评估。
Mutat Res. 1983 Sep;121(3-4):211-23. doi: 10.1016/0165-7992(83)90206-3.

引用本文的文献

1
Dual roles of methylglyoxal in cancer.甲基乙二醛在癌症中的双重作用。
Front Oncol. 2025 Apr 25;15:1557162. doi: 10.3389/fonc.2025.1557162. eCollection 2025.
2
Passive cigarette smoke and the renal glyoxalase system.被动吸烟与肾脏乙二醛酶系统
Mol Cell Biochem. 2002 Jan;229(1-2):153-6. doi: 10.1023/a:1017992403656.
3
Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal.甲基乙二醛对大鼠肝脏中γ-谷氨酰转肽酶阳性病灶的诱导和促进作用
Jpn J Cancer Res. 1988 Jun;79(6):666-9. doi: 10.1111/j.1349-7006.1988.tb02218.x.
4
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.乙二醛酶系统:对生物生命基本代谢途径进行功能表征的新进展。
Biochem J. 1990 Jul 1;269(1):1-11. doi: 10.1042/bj2690001.