Faggin P, Bassi A M, Finollo R, Brambilla G
Mutat Res. 1985 Nov;144(3):189-91. doi: 10.1016/0165-7992(85)90138-1.
The number of sister-chromatid exchanges (SCEs) per metaphase was determined in Chinese hamster ovary cells after 16 h exposure to methylglyoxal (MG) concentrations ranging from 0.1 to 0.75 mM. MG produced an increase of SCE frequency that proved to be dose-dependent, and to reach a maximum of 2 X baseline at the highest nontoxic concentration (0.5 mM).
将中国仓鼠卵巢细胞暴露于浓度范围为0.1至0.75 mM的甲基乙二醛(MG)中16小时后,测定每个中期的姐妹染色单体交换(SCE)数量。MG使SCE频率增加,这被证明是剂量依赖性的,并且在最高无毒浓度(0.5 mM)下达到基线的2倍最大值。