Patterson T A, Alvarado M C, Rosenzweig M R, Bennett E L
Department of Psychology, University of California, Berkeley 94720.
Neurochem Res. 1988 Jul;13(7):643-7. doi: 10.1007/BF00973282.
The roles of different forebrain structures in stages of memory formation were investigated by injecting agents into either the left medial hyperstriatum ventrale (MHV) or right lateral neostriatum (LNS) close to the time of one-trial taste-avoidance training. With L-glutamate injected into either the left MHV or right LNS 5 minutes pretraining, retention was good 1 minute posttraining but significantly impaired at 5 minutes and each subsequent time point. With emetine injected into either area, retention was still good 60 minutes posttraining but significantly impaired at 90 minutes. With ouabain, retention declined more slowly following injection into the right LNS (at 45 minutes) compared to injection in the left MHV (at 30 minutes). A second experiment confirmed the regional difference in amnesia development produced by ouabain. These results indicate that the duration of short-term memory is longer following inhibition of intermediate-term memory (ITM) in the right LNS, compared to inhibition of ITM in the left MHV.
在单次味觉回避训练前后，通过向左侧内侧腹侧上纹状体（MHV）或右侧外侧新纹状体（LNS）注射药物，研究了不同前脑结构在记忆形成阶段的作用。在训练前5分钟向左侧MHV或右侧LNS注射L - 谷氨酸，训练后1分钟记忆保持良好，但在5分钟及随后的每个时间点均显著受损。向任一区域注射吐根碱后，训练后60分钟记忆保持仍良好，但在90分钟时显著受损。注射哇巴因后，与注射到左侧MHV（30分钟时）相比，注射到右侧LNS（45分钟时）记忆保持下降得更慢。第二个实验证实了哇巴因导致的遗忘发展存在区域差异。这些结果表明，与抑制左侧MHV中的中期记忆（ITM）相比，抑制右侧LNS中的ITM后短期记忆的持续时间更长。
