Sandi C, Patterson T A, Rose S P
Department of Biology, Open University, Milton Keynes, U.K.
Neuroscience. 1993 Jan;52(2):393-401. doi: 10.1016/0306-4522(93)90166-d.
Several lines of evidence (biochemical, neuroanatomical, electrophysiological, and behavioural) have indicated a critical role for the intermediate medial hyperstriatum ventrale of the chick forebrain in the acquisition of a passive avoidance response. Previous lesion studies indicated that bilateral or left, but not right, pretraining intermediate medial hyperstriatum ventrale lesions interfere with the acquisition of this task. We have further analysed this asymmetrical involvement of the intermediate medial hyperstriatum ventrale by use of a monocular learning protocol and intermediate medial hyperstriatum ventrale lesions (sham, bilateral, or unilateral). The results indicated that there is interocular transfer of information of passive avoidance learning between the two eye systems, with a tendency to be more successful from the right eye system to the left than in the opposite direction. As in binocular conditions, bilateral pretraining intermediate medial hyperstriatum ventrale lesions impair learning in monocularly trained animals. Unilateral lesions to either left or right monocularly trained experimental animals resulted in amnesia when they were made to the right intermediate medial hyperstriatum ventrale and the chicks were trained/tested with the left eye open. These results indicate that, although right intermediate medial hyperstriatum ventrale lesions do not result in amnesia in binocular animals, this region is capable of participating in memory acquisition processes. They also suggest a connection between lateralization of intermediate medial hyperstriatum ventrale function in passive avoidance learning and the behavioural and structural visual asymmetries known to occur in chicks.
多条证据线索（生化、神经解剖、电生理和行为学方面）表明，鸡前脑的中间内侧腹侧纹状体在获得被动回避反应中起关键作用。先前的损伤研究表明，双侧或左侧（而非右侧）训练前的中间内侧腹侧纹状体损伤会干扰该任务的获得。我们通过使用单眼学习方案和中间内侧腹侧纹状体损伤（假手术、双侧或单侧）进一步分析了中间内侧腹侧纹状体的这种不对称参与情况。结果表明，被动回避学习的信息在两个眼系统之间存在眼间转移，从右眼系统到左眼的转移往往比相反方向更成功。与双眼条件下一样，双侧训练前的中间内侧腹侧纹状体损伤会损害单眼训练动物的学习。对单眼训练的实验动物的左侧或右侧进行单侧损伤，当损伤右侧中间内侧腹侧纹状体且雏鸡左眼睁开进行训练/测试时，会导致失忆。这些结果表明，尽管右侧中间内侧腹侧纹状体损伤不会导致双眼动物失忆，但该区域能够参与记忆获取过程。它们还表明，在被动回避学习中，中间内侧腹侧纹状体功能的侧化与已知在雏鸡中出现的行为和结构视觉不对称之间存在联系。
