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Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone.

作者信息

Centrella M, McCarthy T L, Canalis E

机构信息

Department of Medicine (Endocrine Division), Saint Francis Hospital and Medical Center, Hartford, CT 06105.

出版信息

Proc Natl Acad Sci U S A. 1988 Aug;85(16):5889-93. doi: 10.1073/pnas.85.16.5889.

DOI:10.1073/pnas.85.16.5889
PMID:2901093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC281870/
Abstract

Transforming growth factor beta (TGF-beta) is produced by bone cells, is abundant in bone matrix, and regulates bone cell biochemical processes. In osteoblast-enriched fetal rat parietal bone cell cultures, low TGF-beta doses increase DNA synthesis, whereas higher levels are less mitogenic, stimulate collagen production, and decrease alkaline phosphatase activity. Parathyroid hormone by itself has minimal effects on these processes, but it opposes the effects of TGF-beta and alters TGF-beta binding to its receptors in osteoblast-enriched cultures. Some functions ascribed to parathyroid hormone in bone may therefore result from alterations in TGF-beta activity, suggesting that the local effects of TGF-beta in bone are under systemic hormonal control.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c765/281870/f87073e13ee5/pnas00295-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c765/281870/e0717a95e7ff/pnas00295-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c765/281870/f87073e13ee5/pnas00295-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c765/281870/e0717a95e7ff/pnas00295-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c765/281870/f87073e13ee5/pnas00295-0142-a.jpg

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本文引用的文献

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Effects of two treatment regimes with synthetic human parathyroid hormone fragment on bone formation and the tissue balance of trabecular bone in greyhounds.两种合成人甲状旁腺激素片段治疗方案对灵缇犬骨形成及小梁骨组织平衡的影响
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Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.成骨细胞中转化生长因子-β2表达增加会导致骨质疏松样表型。
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