Buss D H, Reynolds G D, Cooper M R
Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;55(5):287-92. doi: 10.1007/BF02896587.
Ten cases of multiple myeloma are reported in which there were a large number of plasma cells with excessively convoluted or lobulated nuclei. These cases represent 3% of the 297 evaluable multiple myeloma patients treated at our institution over a 22-year period. All 10 had intermediate or advanced stage disease at the time of diagnosis, and all have died after a mean survival of 19.5 months. Ultrastructural features of 2 cases are described. When found in abundance, such cells can cause difficulty in establishing a morphologic diagnosis of multiple myeloma because of their resemblance to other cell types. Therefore, it may be necessary to perform immunoperoxidase staining and/or electron microscopy to confirm the plasmacytic identity of these cells. The findings add further support to the contention that the presence of excessive nuclear convolutions is not a completely reliable indication of T-cell, as opposed to B-cell, lineage.
报告了10例多发性骨髓瘤病例，其中有大量浆细胞，其细胞核过度卷曲或呈分叶状。这些病例占我们机构在22年期间治疗的297例可评估多发性骨髓瘤患者的3%。所有10例在诊断时均处于中期或晚期疾病，且均在平均存活19.5个月后死亡。描述了2例的超微结构特征。当大量存在时，此类细胞因其与其他细胞类型相似，会给多发性骨髓瘤的形态学诊断带来困难。因此，可能有必要进行免疫过氧化物酶染色和/或电子显微镜检查，以确认这些细胞的浆细胞特性。这些发现进一步支持了以下观点：与B细胞系相反，细胞核过度卷曲的存在并非T细胞系的完全可靠指标。
