二氧化碳在急性高原病中的作用：一项重新发现

Effect of carbon dioxide in acute mountain sickness: a rediscovery.

作者信息

Harvey T C, Raichle M E, Winterborn M H, Jensen J, Lassen N A, Richardson N V, Bradwell A R

机构信息

Birmingham Medical Research Expeditionary Society Medical School, University of Birmingham, England.

出版信息

Lancet. 1988 Sep 17;2(8612):639-41. doi: 10.1016/s0140-6736(88)90465-5.

DOI:10.1016/s0140-6736(88)90465-5

PMID:2901515

Abstract

The effect of adding CO2 to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m.3% CO2 in ambient air increased ventilation and resulted in a rise in PaO2 of between 24% and 40%. There was a 9-28% increase in PaCO2 and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO2 inhalation at high altitude.

摘要

在一次前往海拔5400米的医学考察中，研究了向六名急性高原病患者吸入的空气中添加二氧化碳的效果。环境空气中3%的二氧化碳可增加通气量，并使动脉血氧分压升高24%至40%。动脉血二氧化碳分压升高9%至28%，并减轻了通常在高海拔地区出现的呼吸性碱中毒。急性高原病的症状迅速得到缓解。在三名受试者中，脑血流量增加了17%至39%，从而使大脑的氧气供应得到显著改善。这项研究证实了早期关于在高海拔地区吸入二氧化碳有益效果的观点。