Harvey T C, Raichle M E, Winterborn M H, Jensen J, Lassen N A, Richardson N V, Bradwell A R
Birmingham Medical Research Expeditionary Society Medical School, University of Birmingham, England.
Lancet. 1988 Sep 17;2(8612):639-41. doi: 10.1016/s0140-6736(88)90465-5.
The effect of adding CO2 to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m.3% CO2 in ambient air increased ventilation and resulted in a rise in PaO2 of between 24% and 40%. There was a 9-28% increase in PaCO2 and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO2 inhalation at high altitude.
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