Thyagarajan S P, Subramanian S, Thirunalasundari T, Venkateswaran P S, Blumberg B S
Department of Microbiology, University of Madras, India.
Lancet. 1988 Oct 1;2(8614):764-6. doi: 10.1016/s0140-6736(88)92416-6.
In a preliminary study, carriers of hepatitis B virus were treated with a preparation of the plant Phyllanthus amarus for 30 days. 22 of 37 (59%) treated patients had lost hepatitis B surface antigen when tested 15-20 days after the end of the treatment compared with only 1 of 23 (4%) placebo-treated controls. Some subjects have been followed for up to 9 months. In no case has the surface antigen returned. Clinical observation revealed few or no toxic effects. The encouraging results of this preliminary study recommend continued evaluation of this plant and the active principles isolated from it.
在一项初步研究中，乙肝病毒携带者接受了苦味叶下珠制剂治疗30天。治疗结束后15 - 20天进行检测时，37名接受治疗的患者中有22名（59%）乙肝表面抗原消失，而在23名接受安慰剂治疗的对照组患者中只有1名（4%）出现这种情况。一些受试者已被随访长达9个月，表面抗原均未再出现。临床观察显示几乎没有或不存在毒性作用。这项初步研究的令人鼓舞的结果建议对这种植物及其分离出的活性成分继续进行评估。
