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病例报告:纽约市一家屠宰场发生的三例钩端螺旋体病聚集性病例及首例病例的罕见并发症

Case Report: A Cluster of Three Leptospirosis Cases in a New York City Abattoir and an Unusual Complication in the Index Case.

作者信息

Kupferman Tania, Coffee Megan P, Eckhardt Benjamin J

机构信息

Division of Infectious Diseases and Immunology, NYU School of Medicine, New York, New York.

International Rescue Committee, New York, New York.

出版信息

Am J Trop Med Hyg. 2017 Dec;97(6):1679-1681. doi: 10.4269/ajtmh.17-0545. Epub 2017 Sep 28.

DOI:10.4269/ajtmh.17-0545
PMID:29016310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5805074/
Abstract

We report the case of a 46-year-old male abattoir worker who developed myalgias, shortness of breath, and irritability 2 weeks after sustaining a laceration to the hand with a knife at work. During his hospital evaluation for septic shock he was noted to be febrile, hypotensive, profoundly jaundiced with aseptic meningitis, and renal failure, and was diagnosed with infection confirmed by serum and urine polymerase chain reaction. After standard antibiotic therapy and recovery from severe clinical illness, he developed unilateral orchitis with pyuria secondary to leptospirosis, a well-established complication in the veterinary literature, but of which we offer the first report in humans in the English literature. The case presented was also the index case that uncovered a cluster outbreak of leptospirosis in New York City during the winter of 2016-2017, involving a total of three patients who lived or worked within a block of the abattoir. Two patients survived whereas the third died of pulmonary hemorrhage shortly after seeking medical care.

摘要

我们报告了一例46岁男性屠宰场工人的病例,他在工作中手部被刀割伤2周后出现肌痛、呼吸急促和易怒症状。在他因感染性休克接受住院评估期间,发现他发热、低血压、患有无菌性脑膜炎且黄疸严重,并伴有肾衰竭,血清和尿液聚合酶链反应证实其感染。经过标准抗生素治疗并从严重临床疾病中康复后,他继发钩端螺旋体病出现单侧睾丸炎伴脓尿,这在兽医文献中是一种公认的并发症,但我们在英文文献中首次报道了其在人类中的病例。该病例也是发现2016 - 2017年冬季纽约市钩端螺旋体病聚集性暴发的首例病例,此次暴发共涉及三名居住或工作在屠宰场街区内的患者。两名患者存活,而第三名患者在就医后不久死于肺出血。

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