Antibiotics excretion in canine vaginal and urethral secretions.

Trimethroprim, erythromycin, ampicillin, and rosamicin, a new macrolide antibiotic, were administered to dogs by constant intravenous infusion. Their concentrations in plasma, urine, vaginal and urethral secretions, saliva, and tears were determined by bioassay. Trimethoprim, rosamicin, and, to a lower degree, erythromycin were concentrated in the secretions of the vagina and the urethra whereas the ampicillin concentrations in these secretions never exceeded the simultaneous plasma concentrations. Inasmuch as rosamicin and trimethoprim have antibacterial spectra well suited for the treatment of bacterial urethritis and vaginitis they should be investigated clinically in this respect.