Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Drosophila RNAi Screening Center, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Dev Cell. 2017 Oct 9;43(1):6-9. doi: 10.1016/j.devcel.2017.09.020.
Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype gap" and impact biomedical research.
单基因敲除实验可能无法揭示冗余背景下的功能，而这在具有重叠功能的重复基因（旁系同源物）中经常观察到。我们讨论了研究旁系同源物相关的复杂性，并概述了 CRISPR 技术的最新进展将如何帮助解决“表型差距”问题并影响生物医学研究。
