Research Department of Primary Care & Population Health,University College London (UCL),Rowland Hill St,London,UK.
Division of Psychiatry,UCL,Sixth Floor Maple House,147 Tottenham Court Rd,London,UK.
Psychol Med. 2018 Jul;48(9):1504-1513. doi: 10.1017/S0033291717003014. Epub 2017 Oct 11.
We do not know how primary care treatment of depression varies by age across both psychotropic medication and psychological therapies.
Cohort study including 19 710 people aged 55+ with GP recorded depression diagnoses and 26 276 people with recorded depression symptoms during the period 2009-2013, from 373 General Practices in The Health Improvement Network (THIN) database in England. Main outcomes were initiation of treatment with anti-depressants, anxiolytics, hypnotics, anti-psychotic drugs, referrals to psychological therapies within 6 months of onset.
Treatment rates with antidepressants are high for those recorded with new depression diagnoses (87.1%) or symptoms of depression (58.7%). Treatment in those with depression diagnoses varies little by age. In those with depressive symptoms there was a J-shaped pattern with reduced antidepressant treatment in those in their 60s and 70s followed by increased treatment in the oldest age groups (85+ years), compared with those aged 55-59 years. Other psychotropic drug prescribing (hypnotics/anxiolytics, antipsychotics) all increase with increasing age. Recorded referrals for psychological therapies were low, and decreased steadily with increasing age, such that women aged 75-79 years with depression diagnoses had around six times lower odds of referral (OR 0.17, 95% CI 0.1-0.29) than those aged 55-59 years, and men aged 80-84 years had around seven times lower (OR 0.14, 95% CI 0.05-0.36).
The oldest age groups with new depression diagnoses and symptoms have fewer recorded referrals to psychological therapies, and higher psychotropic drug treatment rates in primary care. This suggests potential inequalities in access to psychological therapies.
我们不知道在精神药物和心理疗法方面,初级保健治疗抑郁症的方法会随年龄变化而如何变化。
这是一项队列研究,纳入了来自英格兰健康改进网络(THIN)数据库的 373 家全科诊所的 19710 名 55 岁及以上有 GP 记录的抑郁症诊断患者和 26276 名有记录的抑郁症症状患者,研究时间为 2009-2013 年。主要结局为抗抑郁药、抗焦虑药、催眠药、抗精神病药物的起始治疗以及发病后 6 个月内接受心理治疗的情况。
对于新诊断为抑郁症(87.1%)或有抑郁症状(58.7%)的患者,抗抑郁药的治疗率很高。有抑郁症诊断的患者的治疗情况随年龄变化不大。在有抑郁症状的患者中,抗抑郁药治疗呈 J 型模式,60 多岁和 70 多岁的患者治疗率降低,而最年长的年龄组(85 岁及以上)的治疗率增加,与 55-59 岁的患者相比。其他精神药物(催眠药/抗焦虑药、抗精神病药)的开具量均随年龄增长而增加。记录的心理治疗转诊率较低,且随年龄增长而稳步下降,以至于新诊断为抑郁症的 75-79 岁女性的转诊可能性比 55-59 岁的女性低约六倍(OR 0.17,95% CI 0.1-0.29),80-84 岁的男性则低约七倍(OR 0.14,95% CI 0.05-0.36)。
新诊断为抑郁症和有抑郁症状的最年长年龄组在初级保健中接受记录的心理治疗转诊较少,而接受精神药物治疗的比例较高。这表明在获得心理治疗方面可能存在不平等。