Blanco M, Pajares J M, Jimenez M L, Lopez-Brea M
Department of Internal Medicine-Gastroenterology, Autonoma University of Madrid, Hospital de la Princesa, Spain.
Scand J Gastroenterol Suppl. 1988;142:107-9.
Campylobacter pylori (Cp) infection has been demonstrated in 59 of 65 (91%) patients with gastric or duodenal ulcer. Patients were included in a double blind study with ranitidine or famotidine for 4-8 weeks. After therapy, all gastric and duodenal ulcers healed but Cp remained in all previously infected patients, associated with chronic inflammation of gastric mucosa. Our results suggest that H2 antagonists do not have any effect either on Cp infection or on concurrent chronic gastritis. At the same time we observed that Cp infection does not disturb the ulcer healing process. However, Cp may be implicated in the persistence of the chronic gastritis and relapses of ulcers.
在65例胃或十二指肠溃疡患者中，有59例（91%）检测出幽门螺杆菌（Cp）感染。这些患者被纳入一项使用雷尼替丁或法莫替丁进行4至8周的双盲研究。治疗后，所有胃和十二指肠溃疡均愈合，但先前感染的患者体内Cp仍然存在，并伴有胃黏膜慢性炎症。我们的结果表明，H2拮抗剂对Cp感染或并发的慢性胃炎均无任何作用。同时我们观察到，Cp感染并不干扰溃疡愈合过程。然而，Cp可能与慢性胃炎的持续存在及溃疡复发有关。
