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乳糜泻和I型糖尿病中新型HLA II类相关结构模式

Novel HLA class II-associated structural patterns in coeliac disease and type I diabetes.

作者信息

Fernandez N, Hitman G A, Festenstein H, Garde L, Labeta M, Walker-Smith J A, Sachs J A

机构信息

Medical Unit, London Hospital Medical College.

出版信息

Clin Exp Immunol. 1988 Jun;72(3):362-6.

PMID:2901925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541555/
Abstract

Cell membrane antigens were precipitated from EBV transformed cell lines by a monomorphic DR monoclonal antibody. Three mutually exclusive patterns with two glycoproteins (g25 and g28) that had not been previously identified, were observed. The first, g25+/g28- was found in all cell lines from 40 healthy individuals; a second, g25-/g28- was found in 4/7 coeliac and 2/4 IDDM patients and a third, g25+/g28+ was found in 3/7 coeliac and 1/4 IDDM patients. RFLP analysis with Class II alpha and beta chain probes and several restriction enzymes did not correlate with either of the disease associated patterns. Several possibilities regarding the identity and mode of action of the two polypeptides are described.

摘要

通过一种单态DR单克隆抗体从EBV转化的细胞系中沉淀出细胞膜抗原。观察到三种相互排斥的模式，涉及两种以前未被鉴定的糖蛋白（g25和g28）。第一种，g25+/g28-在40名健康个体的所有细胞系中均有发现；第二种，g25-/g28-在4/7的乳糜泻患者和2/4的胰岛素依赖型糖尿病（IDDM）患者中被发现；第三种，g25+/g28+在3/7的乳糜泻患者和1/4的IDDM患者中被发现。使用II类α和β链探针以及几种限制酶进行的RFLP分析与任何一种疾病相关模式均无关联。文中描述了关于这两种多肽的身份和作用方式的几种可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a7/1541555/e03165166e33/clinexpimmunol00099-0016-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a7/1541555/e03165166e33/clinexpimmunol00099-0016-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8a7/1541555/e03165166e33/clinexpimmunol00099-0016-b.jpg

相似文献

1
Novel HLA class II-associated structural patterns in coeliac disease and type I diabetes.乳糜泻和I型糖尿病中新型HLA II类相关结构模式
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2
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引用本文的文献

1
Cell-surface expression of human histocompatibility leucocyte antigen (HLA) class II-associated invariant chain (CD74) does not always correlate with cell-surface expression of HLA class II molecules.人类组织相容性白细胞抗原（HLA）II类相关恒定链（CD74）的细胞表面表达并不总是与HLA II类分子的细胞表面表达相关。
Immunology. 1993 Jun;79(2):331-5.

本文引用的文献

1
H-2-linked low-molecular weight polypeptide antigens assemble into an unusual macromolecular complex.与H-2相关的低分子量多肽抗原组装成一种不同寻常的大分子复合物。
Nature. 1984;309(5971):797-9. doi: 10.1038/309797a0.
2
The invariant chains of mouse class II antigens: biochemical properties and molecular relationship.小鼠Ⅱ类抗原的恒定链：生化特性及分子关系
Eur J Immunol. 1984 Jun;14(6):511-7. doi: 10.1002/eji.1830140606.
3
HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals.
HLA-D区域β链DNA内切酶片段在HLA-DR相同的健康个体和胰岛素依赖型糖尿病个体之间存在差异。
Nature. 1983 Jun 30;303(5920):815-7. doi: 10.1038/303815a0.
4
Demonstration of two distinct light chains in HLA-DR-associated antigens by two-dimensional gel electrophoresis.通过二维凝胶电泳证明HLA-DR相关抗原中存在两种不同的轻链。
Eur J Immunol. 1982 Mar;12(3):214-21. doi: 10.1002/eji.1830120309.
5
HLA class II alpha chain gene polymorphisms in patients with insulin-dependent diabetes mellitus, dermatitis herpetiformis, and celiac disease.胰岛素依赖型糖尿病、疱疹样皮炎和乳糜泻患者的人类白细胞抗原II类α链基因多态性
J Clin Invest. 1987 Feb;79(2):609-15. doi: 10.1172/JCI112854.
6
An antiviral T-cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short, DRw11, and DRw13 haplotypes.一个抗病毒T细胞克隆定义了一种功能超型特异性，该特异性由来自DR2短单倍型、DRw11和DRw13单倍型的不同HLA-DR分子共享。
Immunogenetics. 1987;25(2):84-90. doi: 10.1007/BF00364272.
7
Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.肿瘤坏死因子α和β的基因与人类主要组织相容性复合体相关联。
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699-702. doi: 10.1073/pnas.83.22.8699.
8
HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin.干扰素-γ加肿瘤坏死因子或淋巴毒素诱导人胰岛细胞表达HLA-II类分子。
Nature. 1987;326(6110):304-6. doi: 10.1038/326304a0.
9
New HLA DNA polymorphisms associated with autoimmune diseases.
Nature. 1986;322(6074):64-7. doi: 10.1038/322064a0.
10
Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis.HLA - DQ亚区域的特定基因组标记可区分DR4阳性的胰岛素依赖型糖尿病和DR4阳性的血清阳性青少年类风湿性关节炎。
J Exp Med. 1986 Jul 1;164(1):345-50. doi: 10.1084/jem.164.1.345.