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肿瘤坏死因子α和β的基因与人类主要组织相容性复合体相关联。

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

作者信息

Spies T, Morton C C, Nedospasov S A, Fiers W, Pious D, Strominger J L

出版信息

Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699-702. doi: 10.1073/pnas.83.22.8699.

DOI:10.1073/pnas.83.22.8699
PMID:3464978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC386998/
Abstract

The human major histocompatibility complex (MHC) includes the closely linked genes for the tumor necrosis factors alpha and beta. Their location is within the chromosomal segment between HLA-DR and HLA-A or centromeric of HLA-DP. This assignment is based on Southern blot analysis of a number of different MHC deletion mutants and is corroborated by chromosome in situ hybridization.

摘要

人类主要组织相容性复合体（MHC）包含紧密连锁的肿瘤坏死因子α和β基因。它们位于HLA - DR和HLA - A之间的染色体片段内，或HLA - DP的着丝粒一侧。这一定位是基于对多种不同MHC缺失突变体的Southern印迹分析得出的，并通过染色体原位杂交得到了证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/1608e076d2a4/pnas00326-0274-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/20d419432827/pnas00326-0273-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/94beb643fc0d/pnas00326-0273-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/2ca203d1108b/pnas00326-0273-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/2413e99d879b/pnas00326-0273-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/1608e076d2a4/pnas00326-0274-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/20d419432827/pnas00326-0273-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/94beb643fc0d/pnas00326-0273-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/2ca203d1108b/pnas00326-0273-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/2413e99d879b/pnas00326-0273-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3027/386998/1608e076d2a4/pnas00326-0274-a.jpg

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