肿瘤坏死因子α和β的基因与人类主要组织相容性复合体相关联。
Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.
作者信息
Spies T, Morton C C, Nedospasov S A, Fiers W, Pious D, Strominger J L
出版信息
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699-702. doi: 10.1073/pnas.83.22.8699.
Abstract
The human major histocompatibility complex (MHC) includes the closely linked genes for the tumor necrosis factors alpha and beta. Their location is within the chromosomal segment between HLA-DR and HLA-A or centromeric of HLA-DP. This assignment is based on Southern blot analysis of a number of different MHC deletion mutants and is corroborated by chromosome in situ hybridization.
摘要
人类主要组织相容性复合体（MHC）包含紧密连锁的肿瘤坏死因子α和β基因。它们位于HLA - DR和HLA - A之间的染色体片段内，或HLA - DP的着丝粒一侧。这一定位是基于对多种不同MHC缺失突变体的Southern印迹分析得出的，并通过染色体原位杂交得到了证实。
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