Cohen Eytan, Kramer Michal, Shochat Tzippy, Goldberg Elad, Krause Ilan
Department of Medicine F -Recanati, Rabin Medical Center Clinical Pharmacology Unit, Rabin Medical Center Department of Ophthalmology, Rabin Medical Statistical Counseling Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Medicine (Baltimore). 2017 Oct;96(41):e8290. doi: 10.1097/MD.0000000000008290.
To assess a possible relationship between hematocrit level and intraocular pressure (IOP) in both men and women.Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000 and 2013. Hematocrit levels were categorized as low, normal, and high and by sex; IOP values were categorized as < 18 mmHg and ≥18 mmHg.Cross-sectional analysis was performed on 18,424 subjects of mean (standard deviation) age 46 (10) years (68% male). Normal-range hematocrit for men was 42% to 52% and 37% to 47% for women. In men, mean [95% confidence interval CI)] IOP values by hematocrit level were as follows: below-normal hematocrit, 13.3 mmHg (13.2-13.3), normal hematocrit, 13.5 mmHg (13.4-13.5), above-normal hematocrit, 14.3 mmHg (13.5-15.2) (P < .001). Corresponding values in women were 12.9 mmHg (12.8-13.0), 13.0 mmHg (13.0-13.1), and 14.2 mmHg (12.9-15.6) (P = .014). The difference remained significant for men (P < .001) after adjustment for age, hypertension, diabetes, and body mass index. Men (but not women) with a low hematocrit were found to have a significantly lower odds ratio (95% CI) of having IOP ≥18 mmHg than men with normal hematocrit: nonadjusted model, 0.761 (0.631-0.919); adjusted model, 0.771 (0.638-0.932) (P < .01).It is possible that a raised hematocrit level may also contribute to an elevated IOP in men in addition to the classic risk factors.
评估男性和女性的血细胞比容水平与眼压（IOP）之间可能存在的关系。数据收集自2000年至2013年期间在以色列一家筛查中心接受检查的个体的医疗记录。血细胞比容水平按低、正常和高进行分类，并按性别划分；眼压值分为＜18 mmHg和≥18 mmHg。对18424名平均（标准差）年龄为46（10）岁的受试者（68%为男性）进行了横断面分析。男性正常范围的血细胞比容为42%至52%，女性为37%至47%。在男性中，按血细胞比容水平划分的平均[95%置信区间（CI）]眼压值如下：血细胞比容低于正常水平，13.3 mmHg（13.2 - 13.3）；正常血细胞比容，13.5 mmHg（13.4 - 13.5）；血细胞比容高于正常水平，14.3 mmHg（13.5 - 15.2）（P＜0.001）。女性的相应值为12.9 mmHg（12.8 - 13.0）、13.0 mmHg（13.0 - 13.1）和14.2 mmHg（12.9 - 15.6）（P = 0.014）。在对年龄、高血压、糖尿病和体重指数进行调整后，男性的差异仍然显著（P＜0.001）。发现血细胞比容低的男性眼压≥18 mmHg的比值比（95% CI）显著低于血细胞比容正常的男性：未调整模型，0.761（0.631 - 0.919）；调整模型，0.771（0.638 - 0.932）（P＜0.01）。除了经典危险因素外，血细胞比容水平升高也可能导致男性眼压升高。
