a Department of Ophthalmology , Taipei Veterans General Hospital , Taipei , Taiwan.
b Department of Ophthalmology , National Yang-Ming University , Taipei , Taiwan.
Ocul Immunol Inflamm. 2019;27(2):244-250. doi: 10.1080/09273948.2017.1371763. Epub 2017 Oct 11.
To investigate the association between multiple evanescent white dot syndrome (MEWDS) and Epstein-Barr (EB) virus infection.
A prospective, consecutive case series study was performed in patients with the characteristic findings of MEWDS. Patients received EB viral-specific antibody serologic tests.
Five cases of MEWDS who had prodromal flu-like symptoms were enrolled, comprising 2 women and 3 men with a mean age of 34. Mean diopter of myopia was -7.5. During acute onset of MEWDS, EB virus infection was confirmed by positive EB virus serology test. One showed positive EB viral capsid antigen (EB-VCA) IgM, and the other four showed highly elevated titer of EB-VCA IgG more than 1:160. Two months later, paired serum virus serology data showed negative EB-VCA IgM, or prior EB-VCA IgG titer decreased four-fold in the recovery stage.
MEWDS may be associated with acute systemic EB virus infection. Ocular symptoms might develop due to this infection or represent virus-induced autoimmune inflammatory retinitis.
研究多发性一过性白点综合征（MEWDS）与 Epstein-Barr（EB）病毒感染之间的关系。
对具有 MEWDS 特征表现的患者进行前瞻性、连续病例系列研究。患者接受了 EB 病毒特异性抗体血清学检测。
纳入了 5 例有前驱流感样症状的 MEWDS 患者，包括 2 名女性和 3 名男性，平均年龄为 34 岁。平均近视屈光度为-7.5。在 MEWDS 的急性发作期间，通过 EB 病毒血清学检测证实了 EB 病毒感染。1 例患者 EB 病毒衣壳抗原（EB-VCA）IgM 阳性，另外 4 例患者的 EB-VCA IgG 滴度显著升高，超过 1:160。两个月后，配对血清病毒血清学数据显示恢复期 EB-VCA IgM 转为阴性，或之前的 EB-VCA IgG 滴度下降四倍。
MEWDS 可能与急性全身性 EB 病毒感染有关。眼部症状可能是由这种感染引起的，也可能是病毒诱导的自身免疫性炎症性视网膜炎。
