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经限制性内切酶Alu I处理后酿酒酵母的存活情况。

Survival of Saccharomyces cerevisiae after treatment with the restriction endonuclease Alu I.

作者信息

Winckler K, Bach B, Obe G

机构信息

Institut für Biophysik, Freie Universität Berlin, F.R.G.

出版信息

Int J Radiat Biol. 1988 Oct;54(4):563-6. doi: 10.1080/09553008814552001.

DOI:10.1080/09553008814552001
PMID:2902154
Abstract

Treatment of yeast cells proficient in the repair of radiation damage (Saccharomyces cerevisiae) with the restriction endonuclease Alu I leads to a positive dose-effect relationship between inactivation level and enzyme concentration. The data suggest an uptake of the active restriction enzyme into the cells and a relationship between induction of DNA double-strand breaks and cell killing.

摘要

用限制性内切酶Alu I处理具有辐射损伤修复能力的酵母细胞（酿酒酵母），会导致失活水平与酶浓度之间呈现正剂量效应关系。数据表明活性限制酶被细胞摄取，并且DNA双链断裂的诱导与细胞杀伤之间存在关联。

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引用本文的文献

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Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae.内切酶 PvuII 和 EcoRV 诱导的平末端 DNA 双链断裂在酿酒酵母中是修复的不良底物。
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