0.025%溴隐亭滴眼液与0.25%噻吗洛尔滴眼液对正常人类志愿者的降眼压效果比较。
A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers.
作者信息
al-Sereiti M R, Coakes R L, O'Sullivan D P, Turner P
机构信息
Department of Clinical Pharmacology, St Bartholomew's Hospital, London.
出版信息
Br J Clin Pharmacol. 1989 Oct;28(4):443-7. doi: 10.1111/j.1365-2125.1989.tb03525.x.
Abstract
- The ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops was compared in nine healthy human volunteers, using non-contact tonometry. 2. Considering all post-dosing measurements compared with placebo and including the baseline values as continuous independent variables, using multiple linear regression analysis, both bromocriptine and timolol had a significant ocular hypotensive effect (P less than 0.0001) in the treated eye with a significant but lesser effect in the contralateral eye. 3. In the concentrations used, timolol was more efficacious than bromocriptine in lowering intraocular pressure (P less than 0.025). 4. Using other forms of vehicles for bromocriptine to improve efficacy and studying the ocular hypotensive effect of topical application of other dopamine-2-receptor agonists such as pergolide and lisuride was suggested.
摘要
- 使用非接触眼压计，在9名健康志愿者中比较了0.025%溴隐亭滴眼液和0.25%噻吗洛尔滴眼液的降眼压效果。2. 将所有给药后测量值与安慰剂进行比较，并将基线值作为连续自变量，采用多元线性回归分析，溴隐亭和噻吗洛尔在治疗眼均有显著的降眼压作用（P小于0.0001），对侧眼也有显著但较弱的作用。3. 在所用浓度下，噻吗洛尔在降低眼压方面比溴隐亭更有效（P小于0.025）。4. 建议使用溴隐亭的其他剂型载体以提高疗效，并研究其他多巴胺-2-受体激动剂如培高利特和利苏力特局部应用的降眼压效果。
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