Zhang Liuhong, Niaz Shah Iram, Wang Zhen, Zhu Yonghong, Lin Yongcheng, Li Jing, Liu Lan
a School of Marine Sciences , Sun Yat-Sen University , Guangzhou , China.
b Zhongshan School of Medicine , Sun Yat-Sen University , Guangzhou , China.
Nat Prod Res. 2018 Dec;32(24):2887-2892. doi: 10.1080/14786419.2017.1385023. Epub 2017 Oct 12.
One new depsidone, botryorhodine H (1), together with three known analogues, botryorhodines C, D and G (2-4), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds 1-3 showed α-glucosidase inhibitory activity with IC ranging from 8.1 to 11.2 μM, and compound 1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC = 3.09 and 3.64 μM).
通过与约翰逊不动杆菌B2共培养，从红树林内生真菌木霉属菌株307中获得了一种新的缩酚酸酮，葡萄穗霉红素H（1），以及三种已知类似物，葡萄穗霉红素C、D和G（2-4）。通过一维和二维核磁共振分析以及高分辨率质谱确定了其结构。化合物1-3表现出α-葡萄糖苷酶抑制活性，IC范围为8.1至11.2 μM，化合物1对大鼠催乳素瘤MMQ和大鼠垂体腺瘤GH3细胞系表现出强效细胞毒性（IC = 3.09和3.64 μM）。
