Luo Yuyou, Luo Xiongming, Zhang Tong, Li Siyuan, Liu Shuping, Ma Yuxin, Wang Zongming, Jin Xiaobao, Liu Jing, Wang Xin
School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Bioengineering (Basel). 2022 Dec 6;9(12):776. doi: 10.3390/bioengineering9120776.
A mangrove is a unique ecosystem with abundant resources, in which fungi are an indispensable microbial part. Numerous mangrove fungi-derived secondary metabolites are considerable sources of novel bioactive substances, such as polyketides, terpenoids, alkaloids, peptides, etc., which arouse people's interest in the search for potential natural anti-tumor drugs. This review includes a total of 44 research publications that described 110 secondary metabolites that were all shown to be anti-tumor from 39 mangrove fungal strains belonging to 18 genera that were acquired from the South China Sea between 2016 and 2022. To identify more potential medications for clinical tumor therapy, their sources, unique structures, and cytotoxicity qualities were compiled. This review could serve as a crucial resource for the research status of mangrove fungal-derived natural products deserving of further development.
红树林是一个资源丰富的独特生态系统，其中真菌是不可或缺的微生物组成部分。众多源自红树林真菌的次生代谢产物是新型生物活性物质的重要来源，如聚酮化合物、萜类化合物、生物碱、肽等，这激发了人们寻找潜在天然抗肿瘤药物的兴趣。本综述共纳入44篇研究文献，这些文献描述了2016年至2022年间从中国南海采集的18个属的39株红树林真菌菌株产生的110种次生代谢产物，所有这些次生代谢产物均显示具有抗肿瘤活性。为了确定更多用于临床肿瘤治疗的潜在药物，对它们的来源、独特结构和细胞毒性特性进行了汇总。本综述可为值得进一步开发的红树林真菌衍生天然产物的研究现状提供重要参考。
