Mansur R B, Brietzke E, McIntyre R S, Cao B, Lee Y, Japiassú L, Chen K, Lu R, Lu W, Li T, Xu G, Lin K
Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Acta Psychiatr Scand. 2017 Dec;136(6):607-614. doi: 10.1111/acps.12822. Epub 2017 Oct 11.
To compare brain-derived neurotrophic factor (BDNF) levels between offspring of individuals with bipolar disorders (BD) and healthy controls (HCs) and investigate the effects of BDNF levels and body mass index (BMI) on brain structures.
Sixty-seven bipolar offspring and 45 HCs were included (ages 8-28). Structural images were acquired using 3.0 Tesla magnetic resonance imaging. Serum BDNF levels were measured using enzyme-linked immunosorbent assay. Multivariate and univariate analyses of covariance were conducted.
Significantly higher BDNF levels were observed among bipolar offspring, relative to HCs (P > 0.025). Offspring status moderated the association between BDNF and BMI (F =4.636, P = 0.034). After adjustment for relevant covariates, there was a trend for a significant interaction of group and BDNF on neuroimaging parameters (Wilks'λ F =1.463, P = 0.052), with significant effects on cerebellar white matter and superior and middle frontal regions. Brain volume and BDNF were positively correlated among HCs and negatively correlated among bipolar offspring. Interactions between BDNF and BMI on brain volumes were non-significant among HCs (Wilks'λ F =2.229, P = 0.357), but significant among bipolar offspring (Wilks'λ F =2.899, P = 0.028).
Offspring status and BMI moderate the association between BDNF levels and brain structures among bipolar offspring, underscoring BDNF regulation and overweight/obesity as key moderators of BD pathogenesis.
比较双相情感障碍（BD）患者后代与健康对照者（HCs）的脑源性神经营养因子（BDNF）水平，并研究BDNF水平和体重指数（BMI）对脑结构的影响。
纳入67名双相情感障碍患者后代和45名健康对照者（年龄8 - 28岁）。使用3.0特斯拉磁共振成像获取结构图像。采用酶联免疫吸附测定法测量血清BDNF水平。进行多变量和单变量协方差分析。
与健康对照者相比，双相情感障碍患者后代的BDNF水平显著更高（P > 0.025）。后代状态调节了BDNF与BMI之间的关联（F = 4.636，P = 0.034）。在调整相关协变量后，组和BDNF对神经影像参数存在显著交互作用的趋势（威尔克斯'λ F = 1.463，P = 0.052），对小脑白质以及额上回和额中回有显著影响。健康对照者的脑容量与BDNF呈正相关，双相情感障碍患者后代的脑容量与BDNF呈负相关。BDNF与BMI对脑容量的交互作用在健康对照者中不显著（威尔克斯'λ F = 2.229，P = 0.357），但在双相情感障碍患者后代中显著（威尔克斯'λ F = 2.899，P = 0.028）。
后代状态和BMI调节双相情感障碍患者后代中BDNF水平与脑结构之间的关联，强调BDNF调节以及超重/肥胖是双相情感障碍发病机制的关键调节因素。
