Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Psychiatry Res. 2019 Apr;274:395-399. doi: 10.1016/j.psychres.2019.02.051. Epub 2019 Feb 20.
Brain-derived neurotrophic factor (BDNF) is deemed to be associated with the psychopathology of bipolar I disorder (BD). However, studies focusing on accuracy of BDNF levels to differentiate these patients from healthy controls (HCs) are scarce. Over a discrete twelve-year period, we investigated serum BDNF levels in patients with BD and compared them to age-, sex- and body mass index (BMI)-matched HCs. There were lower serum BDNF levels in 83 samples with BD than in 222 HCs samples (5.7 ± 4.2 ng/ml vs. 12.2 ± 7.5 ng/ml, F = 46.784). Pearson's correlation test showed significant positive correlations between Young Mania Rating Scale scores and the BDNF levels among 61 manic patients (γ = 0.339). The receiver operating characteristic curve analysis showed BDNF levels demonstrated a moderate accuracy of being able to differentiate BD patients from HCs (AUC = 0.801). The most adequate cut-off points of the BDNF level were 6.74 ng/ml (sensitivity = 82.0%, specificity = 63.9%). Our results support that BDNF demonstrated moderate accuracy to distinguish BD patients from HCs. In the future, greater samples would be required to prove these results.
脑源性神经营养因子（BDNF）被认为与双相情感障碍 I 型（BD）的精神病理学有关。然而，专注于 BDNF 水平准确性以区分这些患者与健康对照者（HCs）的研究很少。在一个离散的十二年期间，我们研究了 BD 患者的血清 BDNF 水平，并将其与年龄、性别和体重指数（BMI）匹配的 HCs 进行了比较。83 例 BD 患者的血清 BDNF 水平低于 222 例 HCs 样本（5.7±4.2ng/ml 与 12.2±7.5ng/ml，F=46.784）。Pearson 相关检验显示，在 61 例躁狂症患者中，Young 躁狂评定量表评分与 BDNF 水平之间存在显著正相关（γ=0.339）。受试者工作特征曲线分析显示，BDNF 水平能够区分 BD 患者与 HCs，具有中等准确性（AUC=0.801）。BDNF 水平的最佳截断点为 6.74ng/ml（灵敏度为 82.0%，特异性为 63.9%）。我们的结果支持 BDNF 具有中等准确性，可以区分 BD 患者与 HCs。未来，需要更大的样本量来验证这些结果。
