CrossTalk opposing view: proton transfer in Hv1 utilizes a water wire, and does not require transient protonation of a conserved aspartate in the S1 transmembrane helix.
作者信息
Bennett Ashley L, Ramsey Ian Scott
机构信息
Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
出版信息
J Physiol. 2017 Nov 15;595(22):6797-6799. doi: 10.1113/JP274553. Epub 2017 Oct 11.
Abstract
摘要
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CrossTalk opposing view: proton transfer in Hv1 utilizes a water wire, and does not require transient protonation of a conserved aspartate in the S1 transmembrane helix.相互矛盾的观点：Hv1中的质子转移利用水链，且不需要S1跨膜螺旋中保守天冬氨酸的瞬时质子化。
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2
CrossTalk proposal: Proton permeation through H 1 requires transient protonation of a conserved aspartate in the S1 transmembrane helix.相互作用提议：质子通过H1的渗透需要S1跨膜螺旋中一个保守天冬氨酸的瞬时质子化。
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本文引用的文献
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Proton currents constrain structural models of voltage sensor activation.质子流限制了电压传感器激活的结构模型。
Elife. 2016 Aug 30;5:e18017. doi: 10.7554/eLife.18017.
2
Insights into the structure and function of HV1 from a meta-analysis of mutation studies.通过对突变研究的荟萃分析深入了解HV1的结构与功能。
J Gen Physiol. 2016 Aug;148(2):97-118. doi: 10.1085/jgp.201611619.
3
Selectivity Mechanism of the Voltage-gated Proton Channel, HV1.电压门控质子通道HV1的选择性机制
Sci Rep. 2015 May 8;5:10320. doi: 10.1038/srep10320.
4
Mapping the gating and permeation pathways in the voltage-gated proton channel Hv1.绘制电压门控质子通道Hv1中的门控和通透途径
J Mol Biol. 2015 Jan 16;427(1):131-45. doi: 10.1016/j.jmb.2014.11.018. Epub 2014 Dec 4.
5
Moving gating charges through the gating pore in a Kv channel voltage sensor.在 Kv 通道电压传感器的门控孔中移动门控电荷。
Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1950-9. doi: 10.1073/pnas.1406161111. Epub 2014 Apr 29.
6
X-ray crystal structure of voltage-gated proton channel.电压门控质子通道的 X 射线晶体结构。
Nat Struct Mol Biol. 2014 Apr;21(4):352-7. doi: 10.1038/nsmb.2783. Epub 2014 Mar 2.
7
Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.孤立电压传感域中电压门控的结构机制。
Nat Struct Mol Biol. 2014 Mar;21(3):244-52. doi: 10.1038/nsmb.2768. Epub 2014 Feb 2.
8
Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hHV1.选择性过滤器的巡游描绘了人类电压门控质子通道 hHV1 的孔道。
J Gen Physiol. 2013 Dec;142(6):625-40. doi: 10.1085/jgp.201311045. Epub 2013 Nov 11.
9
The pore of the voltage-gated proton channel.电压门控质子通道的孔。
Neuron. 2011 Dec 22;72(6):991-1000. doi: 10.1016/j.neuron.2011.11.014.
10
Aspartate 112 is the selectivity filter of the human voltage-gated proton channel.天冬氨酸 112 是人类电压门控质子通道的选择性过滤器。
Nature. 2011 Oct 23;480(7376):273-7. doi: 10.1038/nature10557.
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