Hoffstein V, Rubinstein I, Mateika S, Slutsky A S
Department of Medicine, St Michael's Hospital, Toronto, Ontario, Canada.
Lancet. 1988 Oct 29;2(8618):992-4. doi: 10.1016/s0140-6736(88)90744-1.
To examine the hypothesis that the tendency to raised blood pressure in snorers is associated with nocturnal hypoxaemia and snoring, blood pressure was measured and snoring, oxyhaemoglobin saturation (SaO2), and thoraco-abdominal movements were monitored overnight in 372 snorers. Snoring was quantified as number of snores per hour of sleep (snoring index). The data were analysed by multiple linear regression of diastolic blood pressure against age, body mass index (BMI), apnoea-hypopnoea index (AHI, number of episodes per hour), snoring index, and SaO2. Diastolic blood pressure correlated significantly with BMI, AHI, and mean nocturnal oxygen saturation, but not with the snoring index. However, snoring index correlated with BMI, AHI, and mean nocturnal oxygen saturation. Snoring is thus not a direct risk factor for hypertension, but may influence blood pressure via its association with obesity, obstructive sleep apnoea, and nocturnal hypoxaemia.
为检验打鼾者血压升高倾向与夜间低氧血症及打鼾相关的假说，对372名打鼾者进行了夜间血压测量，并监测了打鼾情况、氧合血红蛋白饱和度（SaO2）以及胸腹运动。打鼾情况以每小时睡眠中的打鼾次数（打鼾指数）进行量化。通过对舒张压与年龄、体重指数（BMI）、呼吸暂停低通气指数（AHI，每小时发作次数）、打鼾指数和SaO2进行多元线性回归分析这些数据。舒张压与BMI、AHI及夜间平均氧饱和度显著相关，但与打鼾指数无关。然而，打鼾指数与BMI、AHI及夜间平均氧饱和度相关。因此，打鼾并非高血压的直接危险因素，但可能通过与肥胖、阻塞性睡眠呼吸暂停及夜间低氧血症的关联来影响血压。
