生长激素对人体葡萄糖代谢和胰岛素抵抗的影响。
Effects of growth hormone on glucose metabolism and insulin resistance in human.
作者信息
Kim Shin-Hye, Park Mi-Jung
机构信息
Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
出版信息
Ann Pediatr Endocrinol Metab. 2017 Sep;22(3):145-152. doi: 10.6065/apem.2017.22.3.145. Epub 2017 Sep 28.
Abstract
Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through insulin-like growth factor 1. The diabetogenic action of GH has been well-described in previous in vivo studies. In this paper, we review the metabolic effects of GH on peripheral tissues focusing on glucose metabolism and insulin resistance, and discuss results from human studies on the long-term effects of GH administration on insulin resistance and hyperglycemia.
摘要
生长激素（GH）对于促进体细胞生长和调节底物代谢至关重要。GH的代谢作用直接或通过胰岛素样生长因子1间接发生在包括肝脏、肌肉、脂肪和胰腺在内的多个组织中。GH的致糖尿病作用在先前的体内研究中已有详细描述。在本文中，我们综述了GH对周围组织的代谢影响，重点关注葡萄糖代谢和胰岛素抵抗，并讨论了关于GH给药对胰岛素抵抗和高血糖长期影响的人体研究结果。
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