a Department of Laboratory Diagnostics , Changzheng Hospital, Second Military Medical University of CPLA , Shanghai , China.
b Department of Pharmacy , Changzheng Hospital, Second Military Medical University of CPLA , Shanghai , China.
Pharm Biol. 2017 Dec;55(1):2153-2160. doi: 10.1080/13880209.2017.1383486.
Salvia przewalskii Maxim. (Lamiaceae) is a Chinese herbal medicine that has long been used for the treatment of cardiovascular disease.
The study investigated the therapeutic efficacy of S. przewalskii total phenolic acid extract (SPE) on immune complex glomerulonephritis (ICG) in rats.
Sixty-two Wistar rats were randomized into six groups. ICG was induced in all groups except normal control group. SPE was administered intragastrically at 24 h intervals for 40 consecutive days. Urine protein (UP), total serum protein (TSP), serum albumin (SA), serum cholesterol (SC) and serum urea nitrogen (SUN) were measured one day before, on day 20 and 40 after SPE administration. On day 40 after SPE administration, the kidneys were removed and prepared into pathologic sections. In addition, kidney wet mass was measured for calculating the kidney wet mass coefficient (KWMC).
UP excretion was reduced significantly on day 20 after SPE administration in all three SPE groups as compared with that in medium group, and this effect was observable continuously until 40 days after SPE administration. Compared with medium group, TSP and SA were increased in all three SPE groups after 40 days treatment, while SC and SUN were decreased. KWMC was decreased significantly in 100 mg/kg SPE group after 40 days treatment compared with that in medium group. Histopathologic analyses showed that renal inflammatory infiltration and kidney intumesce were alleviated in all three SPE groups.
SPE may be a potential therapeutic drug for glomerulonephritis.
context: 丹参（唇形科）是一种中国草药，长期以来一直用于治疗心血管疾病。
本研究旨在探讨丹参总酚酸提取物（SPE）对大鼠免疫复合物性肾小球肾炎（ICG）的治疗作用。
将 62 只 Wistar 大鼠随机分为 6 组。除正常对照组外，其余各组均诱导 ICG。SPE 每天灌胃 1 次，连续 40 天。于 SPE 给药前 1 天、给药后第 20 天及第 40 天检测尿蛋白（UP）、总血清蛋白（TSP）、血清白蛋白（SA）、血清胆固醇（SC）和血清尿素氮（SUN）。SPE 给药后第 40 天取肾，制备病理切片。同时测量肾湿重，计算肾湿重系数（KWMC）。
与中剂量组相比，SPE 各剂量组在 SPE 给药后第 20 天即可显著减少 UP 的排泄，且这一作用可持续至第 40 天。与中剂量组相比，SPE 各剂量组在给药 40 天后 TSP 和 SA 均升高，SC 和 SUN 均降低。SPE 高剂量组给药 40 天后 KWMC 较中剂量组显著降低。组织病理学分析显示，SPE 各剂量组均可减轻肾脏炎性浸润和肾肿大。
SPE 可能是一种治疗肾小球肾炎的潜在药物。
