Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
School of Life Science, Northwestern Polytechnical University, Xi'an, China.
High Alt Med Biol. 2023 Sep;24(3):175-185. doi: 10.1089/ham.2022.0139. Epub 2023 Jul 27.
Li Li, Lin Lin, Bo Wen, Peng-cheng Zhao, Da-sheng Liu, Guo-ming Pang, Zi-rong Wang, Yong Tan, and Cheng Lu. Promising natural medicines for the treatment of high-altitude illness. . 24:175-185, 2023.-High-altitude illness (HAI) is a dangerous disease characterized by oxidative stress, inflammatory damage and hemodynamic changes in the body that can lead to severe damage to the lungs, heart, and brain. Natural medicines are widely known for their multiple active ingredients and pharmacological effects, which may be important in the treatment of HAI. In this review, we outline the specific types of HAI and the underlying pathological mechanisms and summarize the currently documented natural medicines applied in the treatment of acute mountain sickness and high-altitude cerebral edema, high-altitude pulmonary edema, chronic mountain sickness, and high-altitude pulmonary hypertension. Their sources, types, and medicinal sites are summarized, and their active ingredients, pharmacological effects, related mechanisms, and potential toxicity are discussed. In conclusion, natural medicines, as an acceptable complementary and alternative strategy with fewer side effects and more long-term application, can provide a reference for developing more natural antialtitude sickness medicines in the future and have good application prospects in HAI treatment.
李丽、琳琳、博文、赵鹏程、刘大胜、庞国明、王子荣、谭勇、陆成。具有治疗高空病潜力的天然药物。24:175-185, 2023.-高空病 (HAI) 是一种危险的疾病，其特征是体内氧化应激、炎症损伤和血液动力学变化，可能导致肺部、心脏和大脑严重受损。天然药物以其多种活性成分和药理作用而闻名，这可能对 HAI 的治疗很重要。在这篇综述中，我们概述了特定类型的 HAI 和潜在的病理机制，并总结了目前记录在案的天然药物在治疗急性高山病和高原脑水肿、高原肺水肿、慢性高山病和高原肺动脉高压中的应用。总结了它们的来源、类型和药用部位，并讨论了它们的活性成分、药理作用、相关机制和潜在毒性。总之，天然药物作为一种副作用较少、长期应用效果较好的可接受的补充和替代策略，可以为未来开发更多的天然抗高原病药物提供参考，在 HAI 治疗方面具有良好的应用前景。
