Abu-Samak Mahmoud Suleiman, Mohammad Beisan Ali, Abu-Taha May Ibrahim, Hasoun Luai Zidan, Awwad Shady Helmi
1 Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan.
2 Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, Amman, Jordan.
Am J Mens Health. 2018 Mar;12(2):411-419. doi: 10.1177/1557988317735412. Epub 2017 Oct 13.
Sleep deprivation is a common health problem that is growing rapidly worldwide and it is associated with short- and long-term impacts on health. The aim of this study was to detect potential predictors of salivary testosterone (sT) association with sleep deprivation in Arab male university students. In this prospective cohort study, 77 university male students in the age range of 18 to 26 years were divided into two groups, sleep-deprived (SD) participants and non-sleep-deprived (NSD) participants. Sleep deprivation was defined as sleeping less than 5 hr per night. Blood samples and sT were collected from fasting participants to measure serum levels of glucose, lipid profile, leptin, serotonin, sT, and body mass index (BMI) values. The multiple linear correlation model of high-density lipoprotein cholesterol (HDL-C), BMI, and serotonin was positively correlated with sT ( r = .977, p < .05) in the SD group. No correlations were identified with sT in the NSD group. In the SD study group, the multiple linear regression model of HDL-C, BMI, and serotonin was significantly influenced by sT ( R² = .955, p < .05). These predictors together explained approximately 96% of the variance in sT levels in the SD study group. No predictive variables for sT were reported in the NSD group. Results indirectly confirmed the presence of a positive association between sT and sleep deprivation in young men. This association is mediated by three factors, HDL-C, BMI, and serum serotonin, which are collectively considered as part of a significant physiological adaptation to sleep deprivation in young men.
睡眠剥夺是一个常见的健康问题，在全球范围内迅速增加，并且它与对健康的短期和长期影响相关。本研究的目的是检测阿拉伯男性大学生中唾液睾酮（sT）与睡眠剥夺之间关联的潜在预测因素。在这项前瞻性队列研究中，77名年龄在18至26岁之间的大学男生被分为两组，睡眠剥夺（SD）参与者和非睡眠剥夺（NSD）参与者。睡眠剥夺被定义为每晚睡眠少于5小时。从空腹参与者采集血样和sT，以测量血清葡萄糖水平、血脂谱、瘦素、血清素、sT和体重指数（BMI）值。在SD组中，高密度脂蛋白胆固醇（HDL-C）、BMI和血清素的多元线性相关模型与sT呈正相关（r = 0.977，p < 0.05）。在NSD组中未发现与sT的相关性。在SD研究组中，HDL-C、BMI和血清素的多元线性回归模型受sT显著影响（R² = 0.955，p < 0.05）。这些预测因素共同解释了SD研究组中sT水平约96%的方差。NSD组未报告sT的预测变量。结果间接证实了年轻男性中sT与睡眠剥夺之间存在正相关。这种关联由三个因素介导，即HDL-C、BMI和血清血清素，它们共同被视为年轻男性对睡眠剥夺的重要生理适应的一部分。
