Haddock Jody H, Mercante Donald E, Paccione Rose, Breaux Jacob L, Jolley Sarah E, Johnson Jessica L, Connolly Sean E, deBoisblanc Bennett P
Section of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University School of Medicine, New Orleans, LA.
Department of Biostatistics, Louisiana State University School of Medicine, New Orleans, LA.
Ochsner J. 2017 Fall;17(3):250-253.
Digital pupillometry (DP) accurately and precisely measures pupillary responses. Little is known about using DP to measure the sedative effect of isolated propofol administration.
We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.
Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination -1.24 mm, standard error [SE] 0.25 and -0.79 mm, SE 0.13, respectively; ≤0.001 for both). Mean constriction velocity decreased by 0.84 mm/s between baseline and procedural termination 0.001). Pupillary latency increased significantly between baseline and induction (mean change 0.016 seconds, SE 0.007; =0.04) but was not significantly different at other time points.
We speculate that DP may be a useful tool to monitor propofol sedation.
数字瞳孔测量法（DP）能够准确且精确地测量瞳孔反应。关于使用DP来测量异丙酚单独给药的镇静效果，目前所知甚少。
我们对19名接受异丙酚中度镇静的成年人进行了一项横断面研究，在此期间我们使用DP测量瞳孔变化。
异丙酚给药后，最大和最小瞳孔直径显著减小（从基线到手术结束的平均变化分别为-1.24毫米，标准误[SE]为0.25；以及-0.79毫米，SE为0.13；两者均≤0.001）。从基线到手术结束，平均收缩速度降低了0.84毫米/秒（P=0.001）。在基线和诱导期之间，瞳孔潜伏期显著增加（平均变化0.016秒，SE为0.007；P=0.04），但在其他时间点无显著差异。
我们推测DP可能是监测异丙酚镇静效果的有用工具。
