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Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.钠钾激活三磷酸腺苷酶α亚型与双相情感障碍之间的关联。
Biol Psychiatry. 2009 Jun 1;65(11):985-91. doi: 10.1016/j.biopsych.2008.10.033. Epub 2008 Dec 5.
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Determination of serum proteins by means of the biuret reaction.通过双缩脲反应测定血清蛋白。
J Biol Chem. 1949 Feb;177(2):751-66.
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Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders.钠钾ATP酶和内源性类洋地黄化合物与抑郁症的关系。
Biol Psychiatry. 2006 Sep 1;60(5):491-9. doi: 10.1016/j.biopsych.2005.12.021. Epub 2006 May 19.
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Neuronal function and alpha3 isoform of the Na/K-ATPase.神经元功能与钠钾ATP酶的α3亚型
Front Biosci. 2005 Sep 1;10:2373-96. doi: 10.2741/1704.
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Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in the human erythrocyte.膜三磷酸腺苷酶作为人类红细胞中钠和钾主动转运的参与者。
J Biol Chem. 1960 Jun;235:1796-802.
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The effects of sickling on ion transport. I. Effect of sickling on potassium transport.镰状化对离子转运的影响。I. 镰状化对钾离子转运的影响。
J Gen Physiol. 1955 Sep 20;39(1):31-53. doi: 10.1085/jgp.39.1.31.
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Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness.
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Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias.地中海贫血中的氧化损伤与红细胞膜转运异常
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钠钾ATP酶作为血液疾病指标的敏感性。

The sensitivity of Na, K ATPase as an indicator of blood diseases.

作者信息

Omar Abulnaja Kkalid, Ahmed Kherd Ali, Helmi Nawal Mohammed, Abdullah Kumosani Taha, Qarii Mohamad H, Hasan Huwait Etimad, Ashwag Albukhari, Nabil Alaama Mohammed, Abdu Al-Ghamdi Maryam, Salama Moselhy Said

机构信息

Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Experimental Biochemistry unit, King Fahad Medical Research center (KFMRC), Jeddah, Kingdom of Saudi Arabia.

出版信息

Afr Health Sci. 2017 Mar;17(1):262-269. doi: 10.4314/ahs.v17i1.32.

DOI:10.4314/ahs.v17i1.32
PMID:29026401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5636257/
Abstract

BACKGROUND

Blood-related hereditary diseases are widespread in Eastern and SouthWestern regions of Saudi Arabia until recently. In this study, we used Na, KATPase as an enzymatic indicator for the diagnosis of the diseases.

MATERIALS AND METHODS

Individuals with different blood diseases (iron deficiency (n=13), anemia (n=14), thalassemia (n=16) and sickle cell anemia (n=12) were studied for Na, K-ATPase activity in the plasma membrane of red blood cell and compared with those of the healthy ones (n=20) of the same age and gender living in Jeddah, Saudi Arabia.

RESULTS

There was a significant elevation in the specific activity of Na, KATPase in individuals with anemia compared with those of control (0.0094 + 0.001 nmol / mg protein/min versus 0.0061 ± 0.001). On the other hand, there was a significant reduction in enzyme activity in thalassemia (0.0028 ± 0.002 nmol / mg protein/min) and sickle cell anemia cases (0.0042 ±0.001 nmol / mg protein/min) compared to the control group. The cut off value for Na, KATPase activity is 0.005 µmol Pi/min-showing 94% sensitivity and 93% specificity for the differentiation of blood abnormality.

CONCLUSION

It can be recommended that the activity of Na, K-ATPase can be used for the diagnosis of individuals with blood diseases/disorders.

摘要

背景

直到最近，与血液相关的遗传性疾病在沙特阿拉伯的东部和西南部地区仍很普遍。在本研究中，我们使用钠钾ATP酶作为诊断这些疾病的酶指标。

材料与方法

研究了患有不同血液疾病（缺铁性贫血（n = 13）、贫血（n = 14）、地中海贫血（n = 16）和镰状细胞贫血（n = 12））的个体红细胞质膜中的钠钾ATP酶活性，并与生活在沙特阿拉伯吉达的相同年龄和性别的健康个体（n = 20）进行比较。

结果

与对照组相比，贫血个体的钠钾ATP酶比活性显著升高（0.0094 + 0.001纳摩尔/毫克蛋白质/分钟，而对照组为0.0061 ± 0.001）。另一方面，与对照组相比，地中海贫血（0.0028 ± 0.002纳摩尔/毫克蛋白质/分钟）和镰状细胞贫血病例（0.0042 ± 0.001纳摩尔/毫克蛋白质/分钟）的酶活性显著降低。钠钾ATP酶活性的临界值为0.005微摩尔无机磷/分钟，对血液异常的鉴别显示出94%的敏感性和93%的特异性。

结论

可以推荐将钠钾ATP酶的活性用于诊断患有血液疾病/紊乱的个体。