Zarghami Mehran, Rezapour Maryam
Professor, Department of Psychiatry, School of Medicine AND Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Resident, Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Addict Health. 2017 Jan;9(1):59-63.
Loperamide is used as an antidiarrheal drug and is available over-the-counter. It cannot pass the blood-brain barrier and it does not have a considerable abuse potential. It can lead to dangerous cardiac arrhythmia.
Herein, we report a 35-year-old man with a 13-year history of abusing opioids who had undergone detoxification for four times during this period. He underwent detoxification for using 200 mg loperamide daily with anticholinergic agents, clonidine, non-steroidal analgesics, and diazepam. No evidence of arrhythmia was seen in the patient.
Tolerating high doses of loperamide could be dangerous and increases the risk of fatal cardiac arrhythmias.
洛哌丁胺用作止泻药，可在柜台购买。它不能通过血脑屏障，且没有明显的滥用潜力。它可能导致危险的心律失常。
在此，我们报告一名35岁男性，有13年阿片类药物滥用史，在此期间曾4次接受戒毒治疗。他因每天使用200毫克洛哌丁胺并联合使用抗胆碱能药物、可乐定、非甾体类镇痛药和地西泮而接受戒毒治疗。患者未出现心律失常迹象。
耐受高剂量洛哌丁胺可能很危险，并会增加致命性心律失常的风险。
