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通过了解胚胎学准确诊断产前唇腭裂。

Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology.

作者信息

Smarius Bram, Loozen Charlotte, Manten Wendy, Bekker Mireille, Pistorius Lou, Breugem Corstiaan

机构信息

Division of Pediatric Plastic Surgery, Cleft Palate Team, Wilhelmina Children's Hospital, 3584 EA Utrecht, The Netherlands.

Division of Gynecology and Obstetrics, Wilhelmina Children's Hospital, 3584 EA Utrecht, The Netherlands.

出版信息

World J Methodol. 2017 Sep 26;7(3):93-100. doi: 10.5662/wjm.v7.i3.93.

DOI:10.5662/wjm.v7.i3.93
PMID:29026689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5618146/
Abstract

Cleft lip with or without cleft palate (CP) is one of the most common congenital malformations. Ultrasonographers involved in the routine 20-wk ultrasound screening could encounter these malformations. The face and palate develop in a very characteristic way. For ultrasonographers involved in screening these patients it is crucial to have a thorough understanding of the embryology of the face. This could help them to make a more accurate diagnosis and save time during the ultrasound. Subsequently, the current postnatal classification will be discussed to facilitate the communication with the CP teams.

摘要

唇裂伴或不伴腭裂是最常见的先天性畸形之一。参与常规20周超声筛查的超声检查人员可能会遇到这些畸形。面部和腭部以非常独特的方式发育。对于参与这些患者筛查的超声检查人员来说,深入了解面部胚胎学至关重要。这有助于他们做出更准确的诊断,并在超声检查时节省时间。随后,将讨论当前的产后分类,以便于与腭裂治疗团队进行沟通。

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本文引用的文献

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Signaling networks in palate development.腭发育中的信号转导网络。
Wiley Interdiscip Rev Syst Biol Med. 2014 May-Jun;6(3):271-8. doi: 10.1002/wsbm.1265. Epub 2014 Mar 18.
2
Analysis of susceptibility loci for nonsyndromic orofacial clefting in a European trio sample.分析欧洲三亲子样本中非综合征性口腔颌面裂的易感基因座。
Am J Med Genet A. 2013 Oct;161A(10):2545-9. doi: 10.1002/ajmg.a.36141. Epub 2013 Aug 16.
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Thymidylate synthase polymorphisms and risks of human orofacial clefts.胸苷酸合成酶基因多态性与人类口腔颌面部裂隙的风险
巴西唇腭裂患者的医院和医疗服务基础设施评估。
Braz Oral Res. 2024 Nov 8;38:e103. doi: 10.1590/1807-3107bor-2024.vol38.0103. eCollection 2024.
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Distribution of Immunomodulation, Protection and Regeneration Factors in Cleft-Affected Bone and Cartilage.免疫调节、保护和再生因子在腭裂相关骨与软骨中的分布
Diagnostics (Basel). 2024 Oct 4;14(19):2217. doi: 10.3390/diagnostics14192217.
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Outcomes of Xenograft with Platelet-rich Fibrin versus Autogenous Bone in Alveolar Cleft Grafting.富含血小板纤维蛋白与自体骨用于牙槽嵴裂植骨的异种移植效果比较
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Examining Craniofacial and Velopharyngeal Structures in Premature Infants: A Window Into the Womb.检查早产儿的颅面和腭咽结构:子宫内的一扇窗口
J Craniofac Surg. 2024 Jun 12. doi: 10.1097/SCS.0000000000010390.
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J Hum Genet. 2024 Apr;69(3-4):139-144. doi: 10.1038/s10038-024-01222-z. Epub 2024 Feb 6.
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