Greuel J M, Luhmann H J, Singer W
Troponwerke, Department of Neurobiology, Köln, Federal Republic of Germany.
Science. 1988 Oct 7;242(4875):74-7. doi: 10.1126/science.2902687.
Lasting modifications of the receptive fields of neurons in the visual cortex can be induced by pairing visual stimuli with iontophoretic application of the neuromodulators acetylcholine and noradrenaline or the excitatory amino acids N-methyl-D-aspartate (NMDA) and L-glutamate. The modifications are obtained in less than 1 hour and persist for more than 40 minutes. Thus, acetylcholine and norepinephrine have a permissive role in use-dependent neuronal plasticity. These results support the notion of a postsynaptic threshold for neuronal malleability that differs from that of sodium-dependent action potentials.
通过将视觉刺激与神经调质乙酰胆碱、去甲肾上腺素或兴奋性氨基酸N-甲基-D-天冬氨酸（NMDA）和L-谷氨酸的离子电渗疗法相结合，可诱导视觉皮层中神经元感受野的持久变化。这种变化在不到1小时内即可产生，并持续超过40分钟。因此，乙酰胆碱和去甲肾上腺素在依赖使用的神经元可塑性中具有允许作用。这些结果支持了神经元可塑性的突触后阈值概念，该阈值不同于钠依赖性动作电位的阈值。
