Dudek S M, Bear M F
Center for Neural Science, Brown University, Providence, RI 02912.
Science. 1989 Nov 3;246(4930):673-5. doi: 10.1126/science.2573152.
Stimulation of phosphoinositide hydrolysis by excitatory amino acids was studied in synaptoneurosomes of kitten striate cortex at several postnatal ages. Ibotenate and glutamate stimulated phosphoinositide turnover during the second and third postnatal months; N-methyl-D-aspartate and DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) were without effect. The developmental profile of ibotenate-stimulated phosphoinositide turnover parallels the postnatal changes in cortical susceptibility to visual deprivation. The transient increase in ibotenate-stimulated phosphoinositide turnover does not occur in visual cortex of kittens reared in complete darkness.
在出生后几个不同年龄段的小猫视皮层突触神经小体中，研究了兴奋性氨基酸对磷酸肌醇水解的刺激作用。鹅膏蕈氨酸和谷氨酸在出生后的第二个月和第三个月刺激了磷酸肌醇的转换；N-甲基-D-天冬氨酸和DL-α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）则没有作用。鹅膏蕈氨酸刺激的磷酸肌醇转换的发育情况与皮层对视觉剥夺敏感性的出生后变化相似。在完全黑暗环境中饲养的小猫的视皮层中，未出现鹅膏蕈氨酸刺激的磷酸肌醇转换的短暂增加。
