Department of Respiratory Medicine, The Affiliated Jiangyin Hospital of Southeast University, Jiangyin, Jiangsu Province, China.
Eur Rev Med Pharmacol Sci. 2017 Sep;21(18):4098-4103.
To compare the inflammatory factors and immune functions of patients with lung cancer and pulmonary ground-glass attenuation.
A total of 108 patients with pulmonary sarcoidosis treated in our hospital were selected and randomly divided into lung cancer group (Group A, n=32), diffuse ground-glass nodule group (Group B, n=35) and solitary ground-glass nodule group (Group C, n=41) according to the diagnosis results. Levels of inflammatory factors, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10), in serum were detected via enzyme-linked immunosorbent assay (ELISA); the T-lymphocyte subset levels (CD3+, CD4+, CD8+ and CD4+/CD8+) in the immune system of patients in the three groups were detected using the flow cytometer; the levels of immunoglobulins, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM), were detected via immunoturbidimetric assay.
There were no significant differences in the levels of TNF-α, IL-1β, IL-6 and IL-10 in patients between Group A and Group B (p>0.05), but the levels in Group A and Group B were significantly higher than those in Group C (p<0.05). There were no significant differences in the levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in patients between Group A and Group B (p>0.05), but the levels in Group A and Group B were significantly lower than those in Group C (p<0.05). There were no significant differences in the levels of IgG, IgA and IgM in patients between Group A and Group B (p>0.05), but the levels in Group A and Group B were significantly lower than those in Group C (p<0.05).
There are lower inflammation and immune functions in patients with lung cancer and pulmonary ground-glass attenuation. Compared with those in patients with lung cancer and diffuse ground-glass nodules, the inflammatory degree in patients with solitary ground-glass nodules is lower and the immune functions are better. Detecting the inflammatory factors and immune functions of patients can also be used as a differential diagnosis means of lung cancer.
比较肺癌和肺部磨玻璃影患者的炎症因子和免疫功能。
选取我院收治的肺结节病患者 108 例，根据诊断结果分为肺癌组（A 组，n=32）、弥漫性磨玻璃结节组（B 组，n=35）和孤立性磨玻璃结节组（C 组，n=41）。采用酶联免疫吸附法（ELISA）检测血清中炎症因子肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）水平；采用流式细胞仪检测三组患者免疫系统中 T 淋巴细胞亚群（CD3+、CD4+、CD8+和 CD4+/CD8+）水平；采用免疫比浊法检测免疫球蛋白、免疫球蛋白 G（IgG）、免疫球蛋白 A（IgA）和免疫球蛋白 M（IgM）水平。
A 组和 B 组患者 TNF-α、IL-1β、IL-6 和 IL-10 水平比较，差异无统计学意义（p>0.05），但均高于 C 组（p<0.05）；A 组和 B 组患者 CD3+、CD4+、CD8+和 CD4+/CD8+水平比较，差异无统计学意义（p>0.05），但均低于 C 组（p<0.05）；A 组和 B 组患者 IgG、IgA 和 IgM 水平比较，差异无统计学意义（p>0.05），但均低于 C 组（p<0.05）。
肺癌和肺部磨玻璃影患者的炎症反应和免疫功能较低，与肺癌弥漫性磨玻璃结节患者相比，孤立性磨玻璃结节患者的炎症程度较低，免疫功能较好。检测患者的炎症因子和免疫功能也可作为肺癌的鉴别诊断手段。
