Panoptes：基于网络的大规模基因组变异数据探索。
Panoptes: web-based exploration of large scale genome variation data.
机构信息
MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK.
Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
出版信息
Bioinformatics. 2017 Oct 15;33(20):3243-3249. doi: 10.1093/bioinformatics/btx410.
MOTIVATION
The size and complexity of modern large-scale genome variation studies demand novel approaches for exploring and sharing the data. In order to unlock the potential of these data for a broad audience of scientists with various areas of expertise, a unified exploration framework is required that is accessible, coherent and user-friendly.
RESULTS
Panoptes is an open-source software framework for collaborative visual exploration of large-scale genome variation data and associated metadata in a web browser. It relies on technology choices that allow it to operate in near real-time on very large datasets. It can be used to browse rich, hybrid content in a coherent way, and offers interactive visual analytics approaches to assist the exploration. We illustrate its application using genome variation data of Anopheles gambiae, Plasmodium falciparum and Plasmodium vivax.
AVAILABILITY AND IMPLEMENTATION
Freely available at https://github.com/cggh/panoptes, under the GNU Affero General Public License.
CONTACT
动机
现代大规模基因组变异研究的规模和复杂性要求探索和共享数据的新方法。为了使这些数据能够为具有不同专业领域的广大科学家群体所利用，需要一个统一的探索框架，这个框架应该是易于访问、连贯和用户友好的。
结果
Panoptes 是一个开源软件框架，用于在网络浏览器中协作式可视化探索大规模基因组变异数据及其相关元数据。它依赖于一些技术选择，这些选择使它能够在非常大的数据集上近乎实时地运行。它可以用于连贯地浏览丰富的混合内容，并提供交互式可视化分析方法来协助探索。我们使用冈比亚按蚊、恶性疟原虫和间日疟原虫的基因组变异数据来说明它的应用。
可用性和实现
可在 https://github.com/cggh/panoptes 上免费获得，遵循 GNU Affero 通用公共许可证。
Zotero 插件