College of Life Sciences, Peking University, Beijing 100871, P.R. China.
Brief Bioinform. 2013 Mar;14(2):131-43. doi: 10.1093/bib/bbs029. Epub 2012 Jul 3.
Genome browser provides a graphical interface for users to browse, search, retrieve and analyze genomic sequence and annotation data. Web-based genome browsers can be classified into general genome browsers with multiple species and species-specific genome browsers. In this review, we attempt to give an overview for the main functions and features of web-based genome browsers, covering data visualization, retrieval, analysis and customization. To give a brief introduction to the multiple-species genome browser, we describe the user interface and main functions of the Ensembl and UCSC genome browsers using the human alpha-globin gene cluster as an example. We further use the MSU and the Rice-Map genome browsers to show some special features of species-specific genome browser, taking a rice transcription factor gene OsSPL14 as an example.
基因组浏览器为用户提供了一个图形界面，用于浏览、搜索、检索和分析基因组序列和注释数据。基于网络的基因组浏览器可以分为具有多个物种的通用基因组浏览器和物种特异性基因组浏览器。在这篇综述中，我们试图概述基于网络的基因组浏览器的主要功能和特点，包括数据可视化、检索、分析和定制。为了简要介绍多物种基因组浏览器，我们以人类α-珠蛋白基因簇为例，描述了 Ensembl 和 UCSC 基因组浏览器的用户界面和主要功能。我们进一步使用 MSU 和 Rice-Map 基因组浏览器，以水稻转录因子基因 OsSPL14 为例，展示了物种特异性基因组浏览器的一些特殊功能。
